It’s been more than six years since the FDA’s first approval of an oncolytic virus – Amgen Inc.’s melanoma drug Imlygic (talimogene laherparepvec) – and it’s easy to argue that progress in the field has been overshadowed by success with other immunotherapy types such as checkpoint inhibitors. Though the FDA hasn’t approved any more oncolytic viruses since then, Phoenix-based Oncomyx Therapeutics Inc. is one of several companies trying to change that.

PERTH, Australia – Health care artificial intelligence (AI) company Harrison.ai has raised AU$129 million (US$97 million) in a series B round that will expand the company’s global footprint by commercializing its comprehensive clinical AI applications.

LONDON – Quell Therapeutics Ltd. has raised $156 million in an oversubscribed series B, enabling it to start a phase I/II trial of its engineered T regulatory (Treg) cell therapy for promoting long-term immune tolerance in liver transplant patients, averting the need for chronic immunosuppression.

Ieso Digital Health Ltd. raised £39 million (US$52.5 million) in financing to develop new tools for its digital cognitive behavioral therapy (CBT) service. Investment firm Morningside led the series B round with Sony Innovation Fund and existing shareholders IP Group, Molten Ventures and Ananda Impact Ventures also participating. Ieso’s digital platform connects users to mental health practitioners for text-based therapy.

Sense Biodetection Ltd. closed a $65 million series B investment round on a high note with an additional $15 million pouring in from previous investors. The Abingdon, England-based company raised $50 million in a first tranche of the round in April. Koch Disruptive Technologies LLC, a subsidiary of Koch Industries Inc., led both parts of the round.

Generate Biomedicines Inc., a company building a machine learning platform to discover new protein therapies, raised $370 million in series B financing supported by its founder, Flagship Pioneering, and institutional co-investors. Its team plans to have multiple preclinical programs by year-end with several moving to the clinic in 2023.

Ankyra Therapeutics Inc., a company developing new cytokine immunotherapies to boost localized antitumor immune responses, closed a $45 million series B financing. Proceeds from the round will be used to advance the Boston-based company's lead molecule, ANK-101, through IND-enabling studies and into phase I trials starting at the beginning of 2023, as well as to advance additional cytokine programs, it said.

After signing a potential $1.2 billion cell therapy deal with Vertex Pharmaceuticals Inc. in August, Arbor Biotechnologies Inc. has raised $215 million in series B financing to advance next-generation precision gene editing therapeutics.

Antios Therapeutics Inc. followed up its $96 million series B financing in April with another $75 million series B-1 round that reflects faith in the potential of lead candidate ATI-2173, bound for phase IIb investigation as the backbone of a once-daily, curative regimen in chronic hepatitis B virus (HBV) infection.

Shouti Inc. raised $100 million in a series B round led by BVF Partners LP to advance its discovery platform for designing oral medicines and to speed up the development of its candidates. The Shanghai and California-based company has secured a total of $158 million in funding so far.