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BioWorld - Thursday, June 8, 2023
Home » Topics » Newco news

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Silhouette made of crumpled paper illustrating depression
Newco news

Lusaris tackling treatment-resistant depression with neuroplastogen approach

Dec. 28, 2022
By Jennifer Boggs
No Comments
Over the past few years, the pandemic clearly has put a spotlight on vaccines and the infectious disease space. But the struggle to adjust in COVID-19’s wake also brought into stark relief another high unmet need. “Coming out of COVID, there was a mental health focus coming into play,” said Andrew Levin, partner and managing director at investment firm RA Capital Management who is also serving as interim CEO at Lusaris Therapeutics Inc., a 2021 startup targeting neuropsychiatric and neurological conditions, with an initial focus on treatment-resistant depression.
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T cells
Newco news

NXI Therapeutics reawakens interest in coronin-1 as autoimmune disease target

Dec. 19, 2022
By Cormac Sheridan
No Comments
Dialing down the immune response remains at the heart of myriad drug development efforts in autoimmune disease. Targeting cytokines, such as tumor necrosis factor alpha or interleukin-12 (IL-12) and IL-23, IL-6, or IL-17, or modulating immune cell trafficking by targeting sphingosine-1-phosphate receptor or integrins, are therapeutic mainstays. But chronic immunosuppression and all its attendant safety concerns is the price that many autoimmune disease patients pay to remain in remission.
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Porphyromonas gingivalis

Keystone Bio linking oral health with systemic benefit

Dec. 5, 2022
By Cormac Sheridan
No Comments
The age-old separation of dentistry from medicine is deeply embedded in education and professional practice. Given the great advances in both disciplines in recent decades, there is a reasonable argument to be made for maintaining the divide.
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Tumor with FMRP-deficient cancer cells.
Newco news

Opna Bio recasts mental retardation protein as cancer immunotherapy target

Nov. 22, 2022
By Anette Breindl
No Comments
Swiss-American startup Opna Bio SA launched this week with a $38 million series A, a Science paper on one of its targets and a pipeline stretching from preclinical to phase II.
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Coins and seedling
Newco news

Fundamental discovery for halting neurodegeneration draws €10M seed round

Nov. 17, 2022
By Nuala Moran
No Comments
Fundamental Pharma GmbH has raised €10 million (US$10.3 million) in a seed round to develop a new class of glutamate inhibitors, after uncovering a route to maintaining the protective effects of the neurotransmitter in the synapses while preventing neurotoxicity when it is released elsewhere.
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Viruses
Newco news

Atriva taking host-targeted antiviral approach into basket study

Nov. 11, 2022
By Jennifer Boggs
No Comments
Atriva Therapeutics GmbH, a small firm founded in 2015 to develop a host-targeted antiviral approach for treating respiratory viral infections, seems to have found itself in thick of it. As the U.S. CDC and other health agencies warn of an uptick in respiratory viral infections – the so-called “tripledemic” of influenza, respiratory syncytial virus and COVID-19 – the German company is gearing up to launch a basket trial testing lead candidate zapnometinib in all three indications.
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Eye illustration
Newco news

Breye launched to develop oral therapy for diabetic retinopathy

Nov. 10, 2022
By Nuala Moran
No Comments
Newco Breye Therapeutics ApS is poised to repurpose an intravenously administered drug that failed in ischemia reperfusion injury as an orally available treatment for diabetic retinopathy, after closing a €4 million (US$4.1 million) seed round.
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Eye and DNA
Newco news

Replay launches first HSV-focused firm, Eudora, with eye on retinal disease

Nov. 1, 2022
By Nuala Moran
No Comments
“Big genomics” specialist Replay Holdings LLC has unveiled the first of four satellite genomic medicine companies it is forming to apply its high capacity herpes simplex viral (HSV) vector to next generation gene therapies. Eudora Therapeutics will specialize in inherited retinal eye diseases. It arrives on the scene with programs targeted at retinitis pigmentosa, Stargardt disease and Usher syndrome type 1B.
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Vaccinia virus
Newco news

Startup Vacv emerges with $3M and new oncolytic virus strategy

Oct. 27, 2022
By Nuala Moran
No Comments
Newco Vacv Biotherapeutics Ltd. has raised $3 million in a seed round to complete preclinical development of next-generation oncolytic viruses that are engineered to overcome previous shortcomings of this modality.
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DNA and data illustration
Newco news

Startup Enhanc3D raises £10M for high-res genome mapping platform

Oct. 25, 2022
By Nuala Moran
No Comments
Enhanc3D Genomics Ltd. has raised £10 million (US$11.3 million) in a series A round to advance development of its Genlink3D technology for directly linking gene regulators in non-coding DNA to their target protein coding genes.
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