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BioWorld - Sunday, December 10, 2023
Home » Topics » Regulatory » Patents

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Cardiovascular

VHL ligands reported in Genentech patent

Dec. 5, 2023
No Comments
A Genentech Inc. patent discloses new benzothiazole compounds acting as von Hippel-Lindau disease tumor suppressor (VHL) inhibitors and reported to be useful for the treatment of ischemia, cancer and anemia.
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Cancer

Prelude Therapeutics patents SMARCA2 and SMARCA4 protein degraders for treatment of cancer

Dec. 5, 2023
No Comments
Research at Prelude Therapeutics Inc. has led to the development of SMARCA2 and/or SMARCA4 degradation inducers.
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Spark-earpiece
Patents

Spark Biomedical reveals new uses for its neurostimulator earpieces

Dec. 4, 2023
By Simon Kerton
No Comments

Spark Biomedical Inc. is seeking patent protection for the use of its transcutaneous auricular neurostimulation (tAN) platform for treating stress and improving performance in stressful situations while controlling bleeding.


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Substance Use & Poisoning

Idorsia Pharmaceuticals identifies new orexin OX1 and OX2 receptor antagonists

Dec. 4, 2023
No Comments
Idorsia Pharmaceuticals Ltd. researchers have prepared and tested new thiazoloaryl-methyl substituted cyclic hydrazine-N-carboxamide derivatives acting as orexin OX1 and OX2 receptor antagonists. They are reported to be useful for the treatment of substance abuse and dependence, anxiety, cognitive, sleep, eating and mood disorders.
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Cancer

Roche divulges EGFR mutant inhibitors for NSCLC

Dec. 4, 2023
No Comments
An F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. patent describes indole derivatives acting as EGFR L858R mutant, T790M/L858R double mutant, T790M/L858R/C797S triple mutant and/or L858R/C797S double mutant allosteric inhibitors reported to be useful for the treatment of non-small-cell lung cancer (NSCLC).
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Cancer

Wake Forest University designs doxorubicin codrugs with reduced cardiotoxicity

Dec. 4, 2023
No Comments
Work at Wake Forest University has led to the development of an H2O2-responsive doxorubicin hybrid codrug able to release H2S (acting as cardioprotective agent). They are reported to be useful for the treatment of cancer.
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Cancer

New NLRP3 inflammasome inhibitors reported in Ventus Therapeutics patent

Dec. 4, 2023
No Comments
Ventus Therapeutics US Inc. has disclosed oxoindolinyl amide derivatives acting as NLRP3 inflammasome inhibitors. As such, they are reported to be useful for the treatment of cancer, metabolic, autoimmune diseases, liver, renal, respiratory, cardiovascular and inflammatory disorders, among others.
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Ocular

Character Biosciences patents new polypeptides for AMD

Dec. 4, 2023
No Comments
A Character Biosciences Inc. patent describes polypeptides acting as low-density lipoprotein receptor (LDLR) ligands and reported to be useful for the treatment of age-related macular degeneration (AMD).
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Cancer

Synrx Therapeutics discovers new POLθ inhibitors for cancer

Dec. 1, 2023
No Comments
Hangzhou Synrx Therapeutics Technology Co. Ltd. has described heterocyclic compounds acting as DNA polymerase θ (POLθ) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Betta Pharmaceuticals presents new EZH2 inhibitors for cancer

Dec. 1, 2023
No Comments
Betta Pharmaceuticals Co. Ltd. has divulged histone-lysine N-methyltransferase EZH2 inhibitors reported to be useful for the treatment of cancer.
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