Osaka University has identified radiolabeled tyrosine derivatives targeting large neutral amino acids transporter small subunit 1 (SLC7A5; LAT1) reported to be useful for the treatment of cancer.

Neurocrine Biosciences Inc. has synthesized vesicular monoamine transporter 2 (VMAT2) inhibitors reported to be useful for the treatment of hyperkinesia and psychosis.

Merck Sharp & Dohme LLC has disclosed phthalazine derivatives acting as NLRP3 inflammasome inhibitors reported to be useful for the treatment of atherosclerosis, nonalcoholic steatohepatitis (NASH; metabolic dysfunction-associated steatohepatitis [MASH]), neuroinflammation, inflammatory skin disease, inflammatory joint disease, autoimmune disease, Alzheimer’s disease and Parkinson’s disease, among others.

University of California Oakland has described potassium channel subfamily K member 2 (TREK-1; KCNK2) and/or potassium channel subfamily K member 10 (TREK2; KCNK10) activators reported to be useful for the treatment of Caisson disease (decompression sickness), depression, headache, pulmonary hypertension, insomnia, chronic pain, lung and neuronal Injury.

Guangzhou Vinnocent Pharmaceutical Ltd. has divulged cytochrome P450 11B1, mitochondrial (CYP11B1; steroid 11-β-monooxygenase) and cytochrome P450 11B2, mitochondrial (CYP11B2; aldosterone synthase; ALDOS) inhibitors reported to be useful for the treatment of anxiety disorders, Cushing syndrome, cancer, diabetic nephropathy, fibromyalgia, heart failure, nonalcoholic steatohepatitis (NASH; metabolic dysfunction-associated steatohepatitis [MASH]) and obesity, among others.

University of Antwerp has identified substituted phenothiazines acting as ferroptosis inhibitors potentially useful for the treatment of acute renal failure, sepsis, ischemia-reperfusion injury, neurological and iron metabolism disorders, transplant rejection and chronic kidney disease, among others.

Researchers at Oncopia Therapeutics Inc. (dba Proteovant Therapeutics Inc.) and University of Michigan have synthesized proteolysis targeting chimera (PROTAC) compounds comprising a Von Hippel-Lindau disease tumor suppressor (VHL) binding moiety covalently linked to a probable global transcription activator SNF2L2 (SMARCA2; BAF190B; SNF2-α) and/or transcription activator BRG1 (SMARCA4; BAF190A; SNF2-β) targeting moiety through a linker.

Scientists at Jisikai (Suzhou) Pharmaceutical Co. Ltd. and Yaopharma Co. Ltd. have disclosed polycyclic N-heterocyclic ketone compounds reported to be useful for the treatment of HIV infection.

Onkure Inc. has described phosphatidylinositol 3-kinase (PI3K) inhibitors reported to be useful for the treatment of cancer, congenital lipomatous overgrowth, vascular malformations, epidermal naevi and skeletal abnormalities and scoliosis (CLOVES syndrome), and PIK3CA-related overgrowth spectrum (PROS).

Sironax Ltd. has divulged nicotinamide phosphoribosyltransferase (NAmPRTase; Nampt) activators reported to be useful for the treatment of cancer, neurodegeneration, inflammation, and mitochondrial, metabolic, cardiovascular, muscle and renal disorders, among others.