Indolinone derivatives acting as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1; HPK1; MEKKK1) inhibitors are detailed in a recent Chengdu Baiyu Pharmaceutical Co. Ltd. patent and described as potentially useful for the treatment of cancer.

FL2022-001 Inc. has patented new 17-β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17-β-HSD 13) inhibitors reported to be useful for the treatment of liver fibrosis and nonalcoholic steatohepatitis.

Work at Praxis Precision Medicines Inc. has led to the identification of new compounds comprising an azaspiroheptane and acting as T-type calcium channel blockers, particularly voltage-dependent T-type calcium channel subunit α-1G (Cav3.1) blockers. As such, they are reported to be useful for the treatment of essential tremor.

Inhibitors of diacylglycerol kinase, particularly diacylglycerol kinase α (DGK-α, DGKA) and/or diacylglycerol kinase ζ (DGK-ζ, DGKZ), believed to be useful for the treatment of cancer and viral infections, have been disclosed by Inventisbio Co. Ltd. and Inventisbio LLC.

Carboexpert Inc. has identified compounds acting as interleukin-1β (IL-1β), interleukin-8 (IL-8; CXCL8) and TNF-α production inhibitors reported to be useful for the treatment of allergy, sepsis and inflammation.

Indolium compounds have been reported in an Emory University patent as potentially useful for the treatment of cancer.

An Oncolinea Pharmaceuticals Inc. patent describes nucleosides acting as DNA repair inhibitors and thus reported to be useful for the treatment of cancer.

A team at the University of Geneva has developed prodrugs of antimicrobial agents and particularly conjugates comprising antimicrobial agents covalently bound to a tocopheryl or tocotrienyl group through a linker with micelle formation ability and improved stability.

Work at Nankai University has led to the development of heparin trisaccharides potentially useful for the treatment of sepsis.