F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have prepared and tested cyclopenta-thieno-diazepine derivatives acting as GABA-A receptor subunit α2β2γ1 positive allosteric modulators (PAMs). As such, they are reported to be useful for the treatment of neurological disorders.
Crestone Inc. and the University of Colorado have reported efflux pump (bacterial) inhibitors potentially useful for the treatment of Gram-negative bacterial infections.
Abbisko Therapeutics Co. Ltd. has patented epidermal growth factor receptor (EGFR; HER1; erbB1) (mutant) inhibitors reported to be useful for the treatment of cancer.
Jiangsu Hengrui Medicine Co. Ltd. and Shanghai Hengrui Pharmaceutical Co. Ltd. have discovered fibroblast growth factor receptor 2 (FGFR2) inhibitors reported to be useful for the treatment of cancer.
Jiangsu Nhwa Pharmaceutical Co. Ltd. and Shujing Biopharma Co. Ltd. have synthesized oxaspiro derivatives acting as μ-opioid receptor agonists reported to be useful for the treatment of pain.
Beijing Tide Pharmaceutical Co. Ltd. proteolysis-targeting chimera (PROTAC) compounds comprising a ubiquitin ligase-binding moiety bonded to a protein phosphatase nonreceptor type 11 (PTPN11)-targeting moiety through a linker.
While the FDA has yet to take a stance on whether risk evaluation and mitigation strategy (REMS) patents can be listed in its Orange Book, the U.S. Court of Appeals for the Federal Circuit weighed in Feb. 24 with a decisive “no” when those patents only claim a system.
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