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BioWorld - Monday, December 11, 2023
Home » Topics » Coronavirus, BioWorld Science

Coronavirus, BioWorld Science
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Free access to BioWorld coronavirus articles

Dec. 11, 2023
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The articles in this collection are from BioWorld’s ongoing coverage of the COVID-19 coronavirus pandemic. They are available for free with registration. Note that we have added three critical tables, which are continuously updated:

Vaccines and therapeutics in development
Diagnostics with U.S. FDA emergency use authorization
Clinical trials of biopharma products affected by COVID-19
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Coronavirus, mRNA and syringe
Infection

Off-target immune response from modified mRNA impacts future development

Dec. 7, 2023
By Nuala Moran
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The Nobel Prize-winning modification that prevents the innate immune system from recognizing injected mRNA as foreign and blocking transcription of the protein it encodes has been found on some occasions to cause ribosomal frameshifting.
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Microscope image of SARS-CoV-2
Infection

New dual inhibitors of host proteases TMPRSS2 and CTSL/CTSB as potential anti-SARS-CoV-2 agents

Dec. 1, 2023
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Current antiviral agents for COVID-19 treatment target viral proteins, which are susceptible to mutation during SARS-CoV-2 evolution. A potential strategy to fight emerging drug resistances is the development of compounds targeting host proteins that are indispensable for the viral life cycle.
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Coronavirus, lungs
Infection

GHRH-R antagonist attenuates pulmonary dysfunction, heart injury in COVID-19 mice

Nov. 27, 2023
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Based on previous studies that have demonstrated the potential of growth hormone-releasing hormone receptor (GHRH-R) antagonists to modulate immune responses to bleomycin lung injury, researchers from the University of Miami and affiliated organizations aimed to evaluate the potential of the GHRH-R antagonist MIA-602 in a mouse model of rVSV-SARS-CoV-2-induced pulmonary dysfunction and heart injury.
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Lab cultures of senescent human lung cells.
Infection

Senolytic therapies suppress long COVID in human organoids, mouse models

Nov. 17, 2023
By Tamra Sami
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Researchers from the University of Queensland discovered that senolytic therapies can suppress long-COVID neuropathology and long-term disorders caused by viral infections by reducing senescent cells, thereby reducing inflammation. Published Nov. 13, 2023, in Nature, the study examined the use of human pluripotent stem cells to generate small mini human brain organoids to screen for antiaging interventions called senolytics that selectively eliminate senescent cells that accumulate with age, lead author Julio Aguado told BioWorld.
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Other news to note for Nov. 16, 2023

Nov. 16, 2023
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Additional early-stage research and drug discovery news in brief, from: Athira Pharma, Chroma Medicine, Cognition Therapeutics, Geovax Labs, Longhorn Vaccines and Diagnostics LLC, Omega Therapeutics.
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Gloved hand holding COVID-19 vaccine vial, syringe
Immune

NIAID selects Tonix’s COVID-19 vaccine candidate TNX-1800 for inclusion in Project Nextgen trials

Nov. 3, 2023
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The National Institute of Allergy and Infectious Diseases (NIAID) is set to conduct a phase I trial with Tonix Pharmaceuticals Holding Corp.’s TNX-1800 (recombinant horsepox virus, live vaccine), a vaccine candidate to protect against COVID-19.
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Structural model of dengue virus.
Infection

2-Thiouridine shows activity against DENV and SARS-CoV-2 ssRNA+ viruses

Oct. 30, 2023
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Researchers from Hokkaido University (Japan) and colleagues have identified 2-thiouridine (s2U) as a broad-spectrum antiviral ribonucleoside analogue, by phenotypic screening of a library of 753 nucleoside analogues for antiviral effects. s2U showed antiviral activity against several ssRNA+ viruses, including DENV, SARS-CoV-2 and its variants of concern.
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Coronavirus spike protein
Infection

GB-0669, a novel MAb targeting the conserved S2 region of spike protein

Oct. 18, 2023
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Researchers from Generate Biomedicines Inc. have detailed the discovery and preclinical characterization of GB-0669, a spike S2-targeted monoclonal antibody (MAb) being developed for the prophylaxis of SARS-CoV-2 infection. Machine learning models were used to identify MAbs targeting the conserved S2 stem helix and RBD class IV region of spike.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

PA-001 attenuates SARS-CoV-2 infection in preclinical models

Oct. 16, 2023
No Comments
Due to the continual emergence of SARS-CoV-2 mutants, there is an unmet clinical need for broad-spectrum treatments for COVID-19. A potential target for novel treatments is the S2 subunit of the SARS-CoV-2 spike (S) protein, which has been highly conserved across the different variants of the virus.
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