Overexpression of the enhancer of zeste homolog 2 (EZH2) has been found in multiple cancer types, such as myeloma, lymphoma, prostate, breast, lung or kidney cancer.
CSPC Pharmaceutical Group Ltd. has announced FDA approval of an IND application for JMT-106, a bispecific fusion protein drug, for glypican-3 (GPC3)-positive solid tumors.
Although treatment outcomes have improved in metastatic melanoma since the use of immune checkpoint blockade (ICB), it still remains a medical challenge. Melanoma cells are thought to adapt several phenotypic states, such as mesenchymal-like state (MES), which may modulate their sensitivity to therapy. An international team of researchers has now investigated the mechanisms behind melanoma cells’ resistance to ICB.
Immune checkpoint inhibitors (ICIs), such as anti-CTLA-4 antibodies, are widely used in cancer immunotherapy. CTLA-4 blockers such as Yervoy (ipilimumab, Bristol Myers Squibb Co.) stimulate antitumoral immune responses, but may also induce toxicity, such as colitis, a common immune-related adverse event that can lead to treatment discontinuation.
Ensem Therapeutics Inc. has disclosed quinazoline derivatives acting as GTPase KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer.
Cellular senescence is a state of terminal cell cycle arrest that is being increasingly explored for its role in cancer therapeutics. Researchers from Ocean University of China reported on AS-1041, an anthraquinone compound derived from the marine compound Aspergiolide A, designed to be used against leukemia due to its pro-senescence effect.
The most comprehensive analysis of gene dependencies in cancer cells to date has identified 370 “highly enriched” drug targets in defined molecular backgrounds. This latest iteration of the Cancer Dependency Map, published in Cancer Cell, Jan. 11, 2024, builds on an earlier version published in 2019, which was based on 324 cell lines.
Insilico Medicine IP Ltd. has divulged cyclin-dependent kinase 8 (CDK8) and/or CDK19 dual inhibitors reported to be useful for the treatment of autoimmune diseases and cancer.
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