Beigene Ltd. has disclosed new Bcl-2-like protein 1 (Bcl-xl; Bcl-X; BCL2L1) inhibitors reported to be useful for the treatment of cancer, viral infections, age-related issues, neurological, immunological and inflammatory disorders.
Jiangsu Hengrui Medicine Co. Ltd. and Shanghai Hengrui Pharmaceutical Co. Ltd. have patented transcriptional coactivator YAP1/transcriptional enhancer factor (TEAD) interaction inhibitors reported to be useful for the treatment of cancer.
Duo Oncology Inc. has been awarded a Small Business Technology Transfer grant by the National Cancer Institute (NCI) to support the development of DUO-307, a combination nanomedicine that delivers cytotoxic polymer conjugated gemcitabine (PGEM) and an immune modulating chemokine receptor type 2 antagonist (CCR2a) to tumor tissue.
Researchers from Neophore Ltd. presented the discovery and preclinical evaluation of NP-1867, a small molecule inhibitor of DNA mismatch repair (MMR) protein PMS2, being developed for the treatment of cancer.
A Hangzhou Highlightll Pharmaceutical Co. Ltd. patent describes new NLRP3 inflammasome inhibitors reported to be useful for the treatment of cancer, inflammation, liver and metabolic disease, neuroinflammation, immunological, cardiovascular and renal disorders.
Yiteng Pharmaceutical Industry (Taizhou) Co. Ltd. has disclosed new inhibitors of cyclin-dependent kinase (CDK), particularly CDK7, reported to be useful for the treatment of cancer.
Indolinone derivatives acting as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1; HPK1; MEKKK1) inhibitors are detailed in a recent Chengdu Baiyu Pharmaceutical Co. Ltd. patent and described as potentially useful for the treatment of cancer.
Protein bromodomain-containing protein 4 (BRD4) is involved in transcription, DNA replication and cell cycle among other processes, and its overexpression has been linked to several types of cancer and immune disorders.
The FDA has accepted Mustang Bio Inc.’s IND application of MB-109 for the treatment of recurrent glioblastoma (GBM) and high-grade astrocytoma. MB-109 is a treatment regimen combining MB-101 (City of Hope-developed IL13Rα2‐targeted CAR T-cell therapy) and MB-108 (Nationwide Children’s Hospital-developed HSV-1 oncolytic virus).
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