Researchers from Jiangsu Hansoh Pharmaceutical Group Co. Ltd. presented the discovery and preclinical evaluation of novel EGFR(T790M/C797S) inhibitors for the treatment of mutant non-small-cell lung cancer (NSCLC).
Research at Insilico Medicine Inc. has led to the development of CDK7/cyclin H inhibitors reported to be useful for the treatment of cancer, infections, autoimmune disorders and inflammation.
Galectin-3 (LGALS3) and/or galectin-9 (LGALS9) inhibitors are reported in a Galecto Biotech AB patent as potentially useful for the treatment of cancer, autoimmune disease, fibrosis, cardiovascular, eye, metabolic, cerebrovascular and inflammatory disorders, among others.
Jeil Pharmaceutical Co. Ltd. has identified receptor-interacting serine/threonine-protein kinase 1 (RIPK1; RIP-1) inhibitors reported to be useful for the treatment of cancer, ulcerative colitis, rheumatoid arthritis, autoimmune disease, cardiovascular disorders and dermatological and inflammatory disorders and neurological disorders, among others.
Researchers from the Chinese University of Hong Kong have identified the Carnobacterium maltaromaticum bacterium as a potential oral probiotic prophylactic to increase vitamin D production and reinvigorate gut microbiota to prevent colorectal cancer (CRC) in women.
Work at Shanghai Haihe Biopharma Co. Ltd. has led to the development of pyrimidine-2(1H)-one-fused bicyclic compounds acting as S-adenosylmethionine synthase isoform type-2 (Mat2A) inhibitors and thus reported to be useful for the treatment of cancer.
Boehringer Ingelheim Pharma GmbH & Co. KG has prepared and tested heteroaromatic compounds described as GTPase KRAS G12C mutant inhibitors and reported to be useful for the treatment of cancer.
A Gossamer Bio Inc. patent describes oxime derivatives that act as diacylglycerol kinase α (DGKA) and/or diacylglycerol kinase ζ (DGKZ) inhibitors and are thus reported to be useful for the treatment of cancer and viral infections.
Researchers from Zhejiang Ocean University and affiliated organizations have reported the discovery and preclinical evaluation of a novel potent histone lysine-specific demethylase 1 (LSD1) inhibitor, FY-21, being developed for the treatment of leukemia.
RSS
