Geode Therapeutics Inc. and Xtalpi Inc. have jointly developed phosphatidylinositol 3-kinase γ (PI3Kγ) inhibitors reported to be useful for the treatment of cancer.
Research at Kumquat Biosciences Inc. has led to the development of Hetero-atom containing compounds described as tyrosine-protein phosphatase non-receptor type 1 (PTPN1; PTP-1B) and (PTPN2; TCPTP) inhibitors and reported to be useful for the treatment of cancer.
TG Immunopharma Co. Ltd. has announced clearance by the FDA for a clinical trial of TGI-6, a bispecific antibody targeting unique tumor-associated antigens (TAA) and CD3 molecules simultaneously, for solid tumors.
Researchers from Innate Pharma SA recently presented preclinical data for IPH-6501, a novel CD20-targeting tetraspecific antibody-based natural killer (NK)-cell engager therapeutic being developed for the treatment of patients with B-cell non-Hodgkin lymphoma (B-NHL).
TYK Medicines Inc. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising cereblon (CRBN) binding moieties covalently linked to EGFR (HER1; erbB1) binding moieties reported to be useful for the treatment of cancer, infections, cardiovascular, immunological, inflammatory and metabolic diseases.
Wuhan Zhongcheng Health Bio-Pharm Technology Co. Ltd. has disclosed aromatic amine compounds acting as Bcr-Abl (Bcr-Abl1) kinase inhibitors reported to be useful for the treatment of neurodegeneration, motor neuron disease, muscular dystrophy, autoimmune disease and inflammation, viral infection, prion infection and cancer.
Gastric cancer (GC) is the fourth most common cause of cancer-related deaths, causing more than 750,000 deaths in 2020. Platinum-based 5-fluorouracil (5-FU) combinations improve survival times compared to surgery alone, but emergent treatment resistance limits long-term clinical benefits. Accordingly, there is an urgent need to develop alternative approaches to overcoming chemoresistance.
Granulosa cell tumors (GCT) are a rare subtype of ovarian cancers, characterized by a slow clinical progression and high rates of late recurrence. With limited treatment options available apart from invasive surgery, targeted therapies would be key. In previous research, scientists at Hudson Institute of Medical Research in Australia demonstrated that targeting X-linked inhibitor of apoptosis protein (XIAP) using small-molecule inhibitors (called Smac-mimetics [SM]) in combination with other compounds could work as a therapeutic approach for GCT.
It has been previously demonstrated that the Bruton tyrosine kinase (BTK) pathway plays a key role promoting cell adhesion and chemotaxis, and that increased adhesion and aberrant chemotaxis contribute to pathogenesis of myelofibrosis (MF). At the recent EHA meeting, researchers from Telios Pharma Inc. presented preclinical data for TL-895, a novel BTK inhibitor currently in clinical development for the treatment of patients with chronic lymphocytic leukemia and MF.
Researchers from INSERM, Samsara Sciences Inc., Sorbonne University and Université Paris Cité have described autophagy inducers reported to be useful for the treatment of cancer, age-related disorders and viral infections.
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