Korea University Research and Business Foundation (KURBF) has disclosed peptides acting as apoptosis inducers reported to be useful for the treatment of cancer.
The FDA has cleared Tango Therapeutics Inc.'s IND application for TNG-462, a next-generation methylthioadenosine-cooperative (MTA) inhibitor of protein arginine methyl transferase 5 (PRMT5) for the treatment of cancers with methylthioadenosine phosphorylase (MTAP) deletion.
Sunshine Lake Pharma Co. Ltd. has divulged benzazepine heterocyclic compounds acting as nuclear receptor RORγT (T cell-specific isoform 2) agonists reported to be useful for the treatment of cancer, rheumatoid arthritis, psoriasis, asthma, systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease and Kawasaki disease, among others.
Shanghai Allist Pharmaceuticals Co. Ltd. has synthesized nitrogen-containing heterocyclic compounds acting as GTPase KRAS (G12D mutant) and (G12V mutant) inhibitors reported to be useful for the treatment of cancer.
Immpact Bio USA Inc. has announced clearance of its IND application by the FDA for IMPT-314, a bispecific OR-Gate autologous chimeric antigen receptor (CAR) T-cell therapy targeting the B-cell antigens CD19 and CD20.
The FDA has cleared Cullinan Oncology Inc.'s IND application for CLN-978, a CD19/CD3 T-cell engaging antibody construct with a human serum albumin (HSA) binding domain to increase serum half-life.
Genetically modified derivatives of the chimeric oncolytic virus (OV) CF33 have previously shown cancer selectivity and oncolytic potency against various solid tumors.
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