Anticancer Bioscience and the J Michael Bishop Institute of Cancer Research have described fused azepine compounds reported to be useful for the treatment of cancer.
Shenzhen Chipscreen Biosciences and Chengdu Chipscreen Pharmaceutical have presented new ATR kinase inhibitors reported to be useful for the treatment of cancer.
With the aim of assessing the implication of gap junction protein connexin 43 (Cx43) in angiogenesis, human pulmonary microvascular endothelial cells were transfected with Cx43-targeting siRNA or Cx43-overexpressing recombinant plasmid vector.
Thryv Therapeutics has presented new pyrazolo[3,4-d]pyrimidin-6-yl-sulfonamide derivatives acting as serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitors reported to be useful for the treatment of cancer, cardiovascular disorders, Lafora disease and Parkinson's disease.
Researchers developed three novel non-small cell lung cancer (NSCLC) patient-derived echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion cell lines, including CUTO8 (variant 1), 9 (variant 1) and 29 (variant 3), as well as a fourth ALK-positive cell line, YU1077 (EML4-ALK variant 3).
Gene expression profiles were retrieved from The Cancer Genomic Atlas lung adenocarcinoma (LUAD) cohort (TCGA - LAUD) (n = 567) and association of CYP4B1 with immune inhibitory components was analyzed to better understand the effect of this member of the CYP superfamily on LUAD immune microenvironment.
BriaCell Therapeutics has secured an exclusive license from University of Maryland, Baltimore County (UMBC) to develop and commercialize soluble CD80 (sCD80) as a biologic agent for the treatment of cancer.
Servier and Vernalis Group have divulged new spirocyclohexane derivatives acting as induced myeloid leukemia cell differentiation protein Mcl-1 inhibitors and apoptosis inducers reported to be useful for the treatment of cancer, immunological disorders and autoimmune diseases.
Alpha-therapy, in which alpha-particle-emitting radionuclides such as 227Th are delivered specifically to tumor tissues, is emerging as a novel strategy for targeted cancer therapy.
RSS