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BioWorld - Tuesday, March 31, 2026
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Home » Topics » BioWorld Science, Endocrine/metabolic

BioWorld Science, Endocrine/metabolic
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Endocrine/metabolic

Islet-targeted gene therapy RJVA-001 leads to durable weight loss in obese mice

Nov. 14, 2024
Researchers from Fractyl Health Inc. presented preclinical data for RJVA-001, a novel pancreatic gene therapy.
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Group of multigenerational, multiracial women

Healing a health divide (that’s long overdue)

Nov. 14, 2024
By Lynn Yoffee
It’s difficult to fathom that the health of half the world’s population is underserved. But it’s a hard truth. There are many conditions that disproportionately impact women. Other conditions and diseases affect women in different ways than men. Decades of research excluding women from clinical trials and investment decisions in male-dominated board rooms have ignored these facts. Though an increasing number of women are now managing investments and driving the research, it’s all still woefully behind. In BioWorld’s new report, Healing the health divide, we’ve highlighted the disparities.
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Endocrine/metabolic

New GLP-1R agonists disclosed in Youngene Therapeutics patent

Nov. 12, 2024
Youngene Therapeutics Co. Ltd. has divulged glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of type 2 diabetes, obesity, prediabetes, metabolic syndrome, stroke, metabolic dysfunction-associated steatohepatitis, cardiovascular and renal disorders, among others.
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Illustration highlighting the adrenal glands and kidneys
Biomarkers

CASZ1 found as possible monogenic cause of primary aldosteronism

Nov. 12, 2024
Primary aldosteronism (PA), caused by bilateral adrenal hyperplasia or aldosteronomas, is the leading cause of endocrine hypertension, with an estimated prevalence of 10%-20% in patients in tertiary hospitals.
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Glucose testing
Endocrine/metabolic

Adipopharma raises funding for phase I trials of PATAS for type 2 diabetes

Nov. 12, 2024
Adipopharma SAS has secured funding to begin phase I trials of PATAS, a compound with a novel mechanism for treating type 2 diabetes.
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Endocrine/metabolic

Setonix Pharmaceuticals discovers new PPARγ modulators

Nov. 11, 2024
Setonix Pharmaceuticals has described peroxisome proliferator-activated receptor γ (PPARγ) modulators reported to be useful for the treatment of inflammatory disorders, metabolic syndrome, obesity, viral infection, cancer, lipid metabolism and glucose metabolism disorders.
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Overweight man sitting on bed facing the window
Endocrine/metabolic

Novel mouse model of MC4R-deficient genetic obesity

Nov. 8, 2024
Researchers from Congruence Therapeutics Inc. have described the development of a mouse model of genetic obesity with a clinically relevant, naturally occurring human melanocortin MC4 receptor (MC4R) mutation.
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Endocrine/metabolic

Corbus presents peripherally restricted CB1 inverse agonist

Nov. 7, 2024
Cannabinoid receptor type 1 (CB1) blockers have been shown to attenuate diet-induced obesity.
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Light micrograph and 3D illustration of adipose tissue.
Endocrine/metabolic

ADPO-002 increases expression of browning genes in adipocytes, adipose tissue

Nov. 7, 2024
Researchers from Adipo Therapeutics LLC presented data from preclinical studies that aimed to assess the γ-secretase inhibitor ADPO-002 (dibenzazepine) for the treatment of obesity.
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Endometriosis
Endocrine/metabolic

Blocking CGRP in endometriosis: two birds with one stone?

Nov. 7, 2024
By Coia Dulsat
Researchers at Harvard Medical School have found that blocking the neuron-released peptide CGRP decreases pain sensitivity and reduces lesion size in endometriosis. Endometriosis is a painful, steroid-dependent inflammatory condition in which tissue similar to that of the endometrial lining grows and establishes outside the uterine mucosa.
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