A recent Hanmi Holdings Co. Ltd. patent describes 1-phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) inhibitors reported to be useful for the treatment of amyotrophic lateral sclerosis, rheumatoid arthritis and Crohn’s disease.

Humanwell Healthcare (Group) Co. Ltd. researchers have prepared and tested AP2-associated protein kinase 1 (AAK1) inhibitors that are reported to be useful for the treatment of bipolar disorder, pain, schizophrenia, Alzheimer’s and Parkinson’s disease.

F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have patented benzodiazepine derivatives acting as GABA(A) receptor subunit α2β2γ1 positive allosteric modulators and reported to be useful for the treatment of neurological disorders.

Michigan State University has identified microtubule-associated protein tau (PHF-tau; MAPT) aggregation inhibitors reported to be useful for the treatment of Alzheimer’s disease.

Research led by the University of Copenhagen and Herlev-Gentofte University Hospital shows that individuals with the eating disorder anorexia nervosa have an abnormal gut microbiome that likely contributes to symptoms associated with the condition. Published in the April 17, 2023, issue of Nature Microbiology, the study showed multiple differences in the species and amounts of bacteria and viruses present in the gut of people with the condition compared with healthy controls.

Shijiazhuang Discovery Medicine Technology Co. Ltd. has divulged pranoprofen derivatives reported to be useful for the treatment of pain and eye disorders.

A study published online in the Proceedings of the National Academy of Sciences on April 14, 2023, showed that strokes cause numerous changes in gene activity in affected microvessels in the brain, and these changes were potentially targetable with existing or future drugs to alleviate brain injury or improve stroke recovery. Treatments available for stroke are very limited and are mainly focused on the recanalization of the obstructed larger cerebral arteries. However, it is known that strokes affect the cerebral microvasculature too, for which there are no current therapies in the clinic.