Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine that has been shown to be involved in metabolic regulation, development of lung disease and support of hematopoiesis, apart from its known roles in the central nervous system. Its plasma levels during sepsis were investigated in this study.
Based on an analysis of critical transcription factors, researchers have stratified rheumatoid arthritis (RA) into two subtypes where gene expression was driven by RAR-α or TGF-β, respectively. The findings, published in Nature Communications on Oct. 20, 2022, by researchers from the University of California, San Diego, give new insights into factors that affect the treatment response in RA, and could point to novel treatment strategies.
The use of cannabis and childhood trauma have been proposed as environmental factors impacting the risk of psychosis. Recent findings have suggested a link between genetic variants in the cannabinoid receptor 1 gene (CNR1) and cannabis use with the risk of psychosis development.
Fibroblasts expressing the tumor suppressor p16INK4a (a marker of senescence) stimulated lung stem cells from young mice to repair damaged tissue, according to a study from the University of California, San Francisco (UCSF). The finding calls into question therapies that eliminate these senescent cells without considering their beneficial role in tissue homeostasis.
About 50% of patients with lung cancer present with metastatic disease; researchers have shown that breast cancer metastasis-suppressor 1 (BRMS1) suppresses metastases in non-small-cell lung cancer and other solid tumors due to its ability to function in a multiprotein histone deacetylase transcriptional corepressor complex or as an E3 ligase to control the degradation of p300 acetyltransferase.
Tavros Therapeutics Inc. and Vividion Therapeutics Inc., a subsidiary of Bayer AG, have entered into a collaboration agreement to discover or target four oncology targets across an initial 5-year term.
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