Flare Therapeutics Inc. has synthesized peroxisome proliferator-activated receptor γ (PPARγ) inverse agonists reported to be useful for the treatment of bladder cancer.
Hitgen Ltd. has divulged NUAK family SNF1-like kinase 1 (NUAK1) and/or NUAK family SNF1-like kinase 2 (NUAK2) inhibitors reported to be useful for the treatment of cancer.
Viva Star Biosciences Ltd. has presented son of sevenless homolog 1 (SOS1)/GTPase KRAS interaction inhibitors reported to be useful for the treatment of cancer.
Deciduous Therapeutics Inc. has disclosed compounds with the ability to activate invariant natural killer T cells (iNKT) and that are reported to be useful for the treatment of obesity.
Cambridge Enterprise Ltd. has synthesized benzo[c][2,6]naphthyridine derivatives acting as casein kinase II isoform alpha prime (CK2α′) inhibitors reported to be useful for the treatment of cancer, diabetes, ischemia, neurodegeneration, viral infections cardiovascular and inflammatory disorders, among others.
Wave Life Sciences Ltd. has highlighted progress with WVE-006, its preclinical Aimer (A-to-I RNA base editing) oligonucleotide candidate for the treatment of alpha-1 antitrypsin deficiency (AATD).
Farnesoid X receptor (FXR) is a bile acid-activated receptor and in the gut it is mainly expressed in the ileum, promoting transcription of fibroblast growth factor-19 (FGF-19), a hormone with positive effects on energetic and glucose homeostasis.
Verismo Therapeutics Inc. has received U.S. orphan drug designation from the FDA for Synkir-110 for the treatment of patients with mesothelin-expressing mesotheliomas.
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