CEPI, the Coalition for Epidemic Preparedness Innovations, will provide seed funding of up to $4.8 million to Intravacc BV to advance the development of a broadly protective betacoronavirus vaccine candidate, which can be delivered intranasally.
Researchers from the International Centre for Genetic Engineering and Biotechnology and colleagues have worked on the systematic identification of cellular proteins that can exert cardioprotective activity after a myocardial infarction (MI).
Covira Inc., a spinout from The University of Chicago, has closed its first dilutive funding via an oversubscribed $1.0 million seed round after raising $9.1 million of nondilutive funding.
Proteolysis targeting chimeras (PROTACs) are drugs that use cancer cells’ own proteasome to selectively degrade essential tumor-driver molecules through E3 ubiquitin ligase binding. Resistance to PROTAC therapy in cultured cells has been shown to involve genomic alterations in their E3 ligase targets.
Revelation Biosciences Inc. has entered into an exclusive worldwide license agreement with Vanderbilt University to develop and commercialize phosphorylated hexaacyl disaccharide (PHAD) for treating or preventing infections.
A research team at Deciphera Pharmaceuticals LLC has discovered novel small-molecule colony-stimulating factor 1 receptor (CSF-1R) inhibitors for the treatment of cancer.
Virtici LLC has been granted a Small Business Innovation Research (SBIR) award by the National Institute of Dental and Craniofacial Research (NIDCR) of the National Institutes of Health (NIH) to advance VTC-886, a first-in-class small molecule for the prevention of Porphyromonas gingivalis infection.
Researchers from Almirall SA and affiliated organizations reported the discovery and preclinical characterization of LAS-200813, a novel peptide inhibitor of the Keap1-Nrf2 protein-protein interaction.
A germline change in a single nucleotide increased the risk by up to 6-fold of developing an isocitrate dehydrogenase (IDH) mutant low-grade glioma. The rs55705857 genotype could serve as a biomarker before surgery to identify an early glioma.
By independently manipulating the lifespan of worms and one of its purported biomarkers, namely, the cessation of vigorous movement (CVM), investigators at the Center for Genomic Regulation (CRG) in Barcelona have demonstrated that the two are driven by partly independent processes.
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