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BioWorld - Thursday, April 23, 2026
Breaking News: Best of BioWorld Science: Q1Breaking News: Best of BioWorld: Q1Breaking News: Best of BioWorld: Q1
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Cancer

Preclinical studies support use of TAS-1440 in combination with anti-PD-1 antibodies for treatment of immunotherapy-resistant cancer

Oct. 28, 2022
Lysine-specific demethylase 1A (LSD1) is a monoamine oxidase encoded by the KDM1A...
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DNA illustration
Biomarkers

Pathogenic ELOC gene variants as a novel cause for VHL disease

Oct. 28, 2022
To date, only inactivating germline variations in the VHL gene have been linked to von Hippel-Lindau...
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Cancer

I-0436650, a potent and selective SHP2 allosteric inhibitor for solid tumor treatment

Oct. 28, 2022
Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) is a target for cancer...
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Illustration of human papillomavirus (HPV) infection
Infection

Clinical trial application for adjuvanted recombinant quadrivalent HPV vaccine accepted in China

Oct. 28, 2022
Jiangsu Recbio Technology Co. Ltd. announced that it has received a notice of acceptance from...
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Microscopic view of of high grade urothelial carcinoma of the ureter in a man.
Cancer

FTX-6746, a new PPARG inverse agonist with efficacy in urothelial cancer animal models

Oct. 28, 2022
Luminal molecular subtype represents most advanced urothelial cancer (UC) cases. It is...
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Concept illustration of cell-free circulating tumor DNA.
Diagnostics

ENA 2022: Limitations and expectations for the analysis of ctDNA on liquid biopsies

Oct. 28, 2022
By Mar de Miguel
Nowadays, there are many tools for cancer diagnosis, from imaging techniques to biopsies. In traditional blood tests, liquid biopsy bursts onto the scene as an explosion of possibilities driven by molecular techniques for the detection and sequencing of proteins or genetic material. But specialists are cautious because they know that in liquid biopsies not everything is detected. At the ENA 2022 session “The role of ctDNA in clinical trials,” Marie Morfouace, a translational researcher at the EORTC, presented “ctDNA in clinical trial practice today,” where she described the balance of the possibilities of the liquid biopsy when confronting it with the results in patients offered by the studies published to date.
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Preclinical conference data for Oct. 27, 2022: ENA

Oct. 27, 2022
New and updated preclinical data presented at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, by: Black Diamond Therapeutics, Exscientia, Flare Therapeutics, Ikena, Nuvalent, Ryvu, Scorpion, Theseus.
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Other news to note for Oct. 27, 2022

Oct. 27, 2022
Additional early-stage research and drug discovery news in brief, from: Equillium, Revelation, Transcode.
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Neurology/Psychiatric

Vanderbilt University synthesizes new mGluR2 negative allosteric modulators

Oct. 27, 2022
Vanderbilt University has patented metabotropic glutamate receptor subtype 2 (mGluR2) negative allosteric modulators reported to be useful for the treatment of depression, anxiety, Alzheimer's disease, obsessive-compulsive and autism spectrum disorders.
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Cancer

Parenchyma Biotech presents new AhR agonists

Oct. 27, 2022
Parenchyma Biotech Inc. has described aryl hydrocarbon receptor (AhR) agonists reported to be useful for the treatment of cancer and autoimmune disease.
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