At first blush, to say that depression occurs with other diseases may seem like belaboring the obvious. After all, to put it in the bluntest possible terms, it’s sad to be sick. But by looking more closely, it soon becomes clear that the association is stronger than that. The strongest association between depression and other diseases, Stefan Gold told the audience at the European College of Neuropsychopharmacology (ECNP) annual conference in Vienna this week, is “not necessarily the most severe or most immediately life-threatening disorders… [it’s] across the spectrum."
Chemoproteomics studies have uncovered multiple potential kinase drug targets in the Plasmodium protozoan that causes malaria, and subsequent screening of approved kinase inhibitor drugs has now thrown up several hits with lethal activity at different stages of the complex life cycle of the parasite. Researchers at the University of Cape Town, South Africa, working with scientists at Glaxosmithkline plc, describe the activity in Plasmodium of one of these kinase inhibitors, the cancer drug sapanisertib, in a paper appearing in Science Translational Medicine, Oct. 19, 2022.
The use of cannabis and childhood trauma have been proposed as environmental factors impacting the risk of psychosis. Recent findings have suggested a link between genetic variants in the cannabinoid receptor 1 gene (CNR1) and cannabis use with the risk of psychosis development.
Medshine Discovery Inc. has presented new pyrimidine derivatives acting as leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2; dardarin) inhibitors reported to be useful for the treatment of neurodegeneration.
Jacobio Pharmaceuticals Co. Ltd. has identified new stimulator of interferon genes protein (STING; TMEM173) agonists reported to be useful for the treatment of cancer.
The Centro Nacional de Investigaciones Oncológicas Carlos III (CNIO) has presented new imidazo[1,2-b]pyridazine-based tricyclic compounds acting as serine/threonine-protein kinase haspin (GSG2) inhibitors and reported to be useful for the treatment of cancer.
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