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BioWorld - Saturday, February 28, 2026
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Infection

Polytope TATX-03 neutralizes SARS-CoV-2 variant BA.2.75 in pseudovirus study

Sep. 15, 2022
Immunoprecise Antibodies Ltd.'s subsidiary, Talem Therapeutics LLC, has shared promising results of a new study conducted by the National Institute of Allergy and Infectious Diseases (NIAID) showing continued resilience of Polytope TATX-03 in broadly neutralizing SARS-CoV-2 variants, including two omicron sublineages that had not been previously tested.
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Musculoskeletal

Domainex nominates DMXD-011 as preclinical drug candidate for interferonopathies

Sep. 15, 2022
Following a research program to identify inhibitors of protein kinases TBK1 and IKK-ε, Domainex Ltd. has nominated DMXD-011 as a preclinical drug candidate.
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Antibodies
Neurology/Psychiatric

Novel antibody protects from HML-2 Env-mediated neurotoxicity

Sep. 15, 2022
Human endogenous retrovirus-K (HERV-K) belongs to the β-retrovirus-like supergroup of viruses, and it has been previously demonstrated that the expression of HERV-K subtype HML-2 envelope (Env) in human neuronal cultures or in transgenic mice resulted in neurotoxicity and neurodegeneration.
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Immuno-oncology

LB-101, a novel LockBody immunotherapy candidate targeting solid tumors

Sep. 15, 2022
Researchers from Centessa Pharmaceuticals plc presented preclinical data for LB-101, a novel first-in-class immunotherapy targeting solid tumors.
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Pill over molecule structures
Neurology/Psychiatric

WLB-83038, a small-molecule candidate with new dual mode of action to treat pain

Sep. 15, 2022
Researchers from Welab Barcelona presented the discovery and preclinical evaluation of novel analgesic candidates with a dual mode of action.
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Cancer cell
Cancer

Arginase inhibitor OATD-02 shows promise in cancer treatment

Sep. 15, 2022
Arginases play key roles in metabolic pathways. Arginase 1 (ARG1) is expressed by myeloid cells in the tumor microenvironment and suppresses the functioning of T and NK cells.
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Drug Design, Drug Delivery & Technologies

Combination strategy enables brain-specific kinase inhibition

Sep. 15, 2022
By Anette Breindl
Using a two-drug combination, researchers at the University of California at San Francisco (UCSF) have been able to achieve brain-specific inhibition of several kinases.
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Cancer

Seoul National University discloses new HSP70 inhibitors

Sep. 15, 2022
Seoul National University has patented chaperone protein DnaK (HSP70) inhibitors acting as antineoplastic enhancing agents reported to be useful for the treatment of cancer.
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Illustration of cancer cells entering the bloodstream.
Cancer

New approach inhibits breast cancer metastases to brain

Sep. 15, 2022
By Mar de Miguel
A new study has unveiled the signaling cascade involved in the progression of brain metastasis from breast cancer. A family of connexins participates in the process that regulate the expression of laminins that favor metastatic cells to colonize the brain.
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Preclinical conference data for Sept. 14, 2022: ESMO

Sep. 14, 2022
New and updated preclinical data presented at the Annual Congress of the European Society for Medical Oncology in Paris, including: Enlivex, GT Biopharma, Immatics, SQZ Biotechnologies.
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