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BioWorld - Saturday, July 18, 2026
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Cancer

Recurium patents new Wee1 inhibitors

July 2, 2026
Recurium IP Holdings LLC has disclosed new Wee1-like protein kinase (Wee1) inhibitors and/or degradation inducers potentially useful for the treatment of cancer.
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Illustration of a tumor
Cancer

CLDN1 targeting suppresses CCA tumor growth

July 2, 2026
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Analyzing different databases, researchers found that CLDN1 was the most highly expressed claudin in tissue samples from patients with cholangiocarcinoma (CCA), both in intrahepatic and extrahepatic CCA subtypes, compared with nontumoral bile duct samples.
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Zika virus particles.
Infection

Oral antiviral IRBM-Z-2 targets Zika infection

July 2, 2026
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Researchers from IRBM SpA described the discovery and preclinical profile of IRBM-Z-2, a Zika virus NS2B-NS3 protease inhibitor.
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Nasal spray
Immune

Abera’s intranasal influenza vaccine shows promise in ferrets

July 2, 2026
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Abera Bioscience AB has completed a ferret study with its intranasal influenza vaccine candidate. The results were consistently strong and encourage the continued development of the program. Abera intends to publish detailed study data in a peer-reviewed scientific journal.
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Brain activity concept illustration
Neurology/psychiatric

Triple-target antidepressant modulates neuroplasticity in vivo

July 2, 2026
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Researchers from Capital Medical University in Beijing, China, aimed to develop novel antidepressant compounds based on the monoaminergic mechanisms of classical antidepressant drugs and the therapeutic potential of 5-HT1A receptor activation.
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Coins and seedling
Aging

Artan closes seed round to support tRNA platform

July 2, 2026
No Comments
Artan Biotechnologies LLC has closed a $1 million seed round to support progression of the company’s proprietary mutation-specific codon suppression platform toward first-in-human development.
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Illustration of RNA strands being delivered by nanoparticles
Gastrointestinal

Ribocure and Madrigal nominate siRNA drug candidate for MASH

July 2, 2026
No Comments
Ribocure Pharmaceuticals AB, a subsidiary of Suzhou Ribo Life Science Co. Ltd., and Madrigal Pharmaceuticals Inc. have achieved the first drug candidate nomination within their siRNA partnership.
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Illustration of CAR T
Immuno-oncology

With GPNMB, CAR T makes further inroads in solid tumors

July 2, 2026
By Anette Breindl
No Comments
Two papers published in the July 1, 2026, issues of Nature and Nature Cancer have reported on preclinical and early clinical data with glycoprotein nonmetastatic melanoma protein B (GPNMB)-targeting CAR T cells in two separate solid tumor types.
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Cardiovascular

Shanghai Zheye Biotechnology patents new ApoA/APOB interaction inhibitors

July 1, 2026
Shanghai Zheye Biotechnology LLC has discovered new phenylpropionic acid derivatives acting as apolipoprotein A (ApoA; LPA)/apolipoprotein B-100 (APOB) interaction inhibitors potentially useful for the treatment of stroke, atherosclerosis, thrombosis, coronary heart disease and aortic valve stenosis.
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Cancer

Adlai Nortye discloses new KRAS G12C inhibitors

July 1, 2026
Adlai Nortye Biopharma Co. Ltd. and Adlai Nortye Pte Ltd. have synthesized new GTPase KRAS G12C mutant inhibitors potentially useful for the treatment of cancer, autoimmune disorders and inflammatory disorders.
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