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Ocular

Development and characterization of a new environmental myopia zebrafish model

Sep. 6, 2024
Researchers from The University of Melbourne published data from a study that aimed to establish a novel myopia model that would facilitate large-scale in vivo studies for investigating molecular signaling and gene-environment interactions in myopia development.
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Oscar-Wilde-illustration.jpg
Aging

Updating Oscar Wilde’s visions of rejuvenation at ARDD 2024

Sep. 6, 2024
By Mar de Miguel
Immortality and eternal youth have been the stuff of myths and legends from ancient times on. Now, in the 21st century, real studies of current medicine could be applied to repair tissues and organs damaged by age. During the 11th Aging Research & Drug Discovery (ARDD) Meeting held at the University of Copenhagen at the end of August, scientists explained the molecular keys of rejuvenation, as many artists imagined in the past.
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Other news to note for Sept. 5, 2024

Sep. 5, 2024
Additional early-stage research and drug discovery news in brief, from: Inflarx, Invivyd.
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3D illustration of RNA
Endocrine/metabolic

Haya, Lilly target metabolic disorders with $1B lncRNA pact

Sep. 5, 2024
By Nuala Moran
The dark matter of long non-coding RNA (lncRNA) is shades brighter, after the signing of two major deals between biotech pioneers and big pharma in the past week. Haya Therapeutics SA announced Sept. 4 that it has sealed a multiyear agreement with Eli Lilly and Co. to apply its lncRNA platform technology to identify targets in obesity and related metabolic disorders.
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Cancer

Jiangsu Vcare Pharmatech discovers new BTK degradation inducers

Sep. 5, 2024
Jiangsu Vcare Pharmatech Co. Ltd. has described proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a Bruton’s tyrosine kinase (BTK) targeting moiety via a linker reported to be useful for the treatment of cancer.
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Respiratory

New P2X3 antagonists for cough disclosed in Nanjing Mingde New Drug Research patent

Sep. 5, 2024
Nanjing Mingde New Drug Research Co. Ltd. has divulged pyrimidinone derivatives acting as P2X purinoceptor 3 (P2RX3; P2X3) antagonists reported to be useful for the treatment of cough.
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Ocular

Merck Sharp & Dohme describes new KLKB1 Inhibitors

Sep. 5, 2024
Merck Sharp & Dohme LLC has identified plasma kallikrein (KLKB1) Inhibitors reported to be useful for the treatment of diabetic retinopathy, retinal vein occlusion, hereditary angioedema, diabetes, pancreatitis, intracerebral hemorrhage, nephropathy and inflammatory disorders.
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Cancer

Arase Therapeutics divulges new PARG inhibitors

Sep. 5, 2024
Arase Therapeutics Inc. has synthesized poly(ADP-ribose) glycohydrolase (PARG) inhibitors reported to be useful for the treatment of cancer.
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Cardiovascular

Nanjing Huanbo Biotechnology patents new GRK2 degradation inducers for PAH

Sep. 5, 2024
Nanjing Huanbo Biotechnology Co. Ltd. has disclosed proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding agent coupled to a β-adrenergic receptor kinase 1 (BARK1; GRK2) targeting moiety via a linker acting as GRK2 degradation inducers.
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Illustration of motor neuron connecting to muscle fiber
Neurology/psychiatric

Grant supports study of NRG Therapeutics’ mPTP inhibitors for ALS

Sep. 5, 2024
NRG Therapeutics Ltd. has been awarded a grant from Target ALS Foundation to support its discovery program for a treatment for amyotrophic lateral sclerosis (ALS).
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