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BioWorld - Wednesday, April 22, 2026
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Immuno-oncology

Preclinical results from a new HPV16/18 mRNA-based vaccine presented

May 8, 2025
No Comments
Metis Pharmaceuticals Inc. recently presented a novel mRNA-encoded human papillomavirus (HPV) 16/18 therapeutic vaccine for HPV-driven malignancies.
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Diabetes glucose monitor
Endocrine/metabolic

Genprex and University of Pittsburgh sign new agreement to study GPX-002 for diabetes

May 8, 2025
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Genprex Inc. and University of Pittsburgh have entered into a new sponsored research agreement (SRA) to study GPX-002, Genprex’s gene therapy for diabetes in animal models of type 1 and type 2 diabetes.
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Intestine
Gastrointestinal

WTX-921: An IL-10 Indukine designed to minimize systemic toxicity

May 8, 2025
No Comments
Interleukin-10 (IL-10) is an immunoregulatory cytokine produced by a variety of immune cells, including type 1 regulatory T cells and macrophages, as well as nonimmune cells such as epithelial cells and fibroblasts.
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Targeted cancer cell
Cancer

Viverita and Boehringer Ingelheim collaborate on cancer target discovery and validation

May 8, 2025
No Comments
Viverita Therapeutics Inc. has established a strategic research collaboration with Boehringer Ingelheim Pharma GmbH & Co. KG aimed at accelerating the discovery and validation of novel therapeutic targets for cancer.
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Ocular

ABI-201 confers protection against age-related macular degeneration

May 8, 2025
No Comments
ABI-201 is an engineered AAV.N54 vector that expresses a soluble CD59 variant and a complement 3 (C3) inhibitor fusion protein. ABI-201 was developed by Avirmax Biopharma Inc. to confer photoreceptor protection against retinal damage. The effects of ABI-201 were tested in a sodium iodate-induced retinal damage model in nonhuman primates, a widely used model for testing therapies for age-related macular degeneration (AMD).
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DNA and silhouette
Genetic/congenital

Organoids plus gene editing bring insights into pediatric metabolic disease

May 8, 2025
By Anette Breindl
No Comments
“I’m a pediatrician in metabolic diseases, and every day in my clinical work I’m confronted with our lack in effective therapies for our patients.” That was the sobering introduction by Sabine Fuchs in her talk at the 2025 Congress of the European Association for the Study of the Liver in Amsterdam this week. The nature of metabolic diseases makes it difficult to develop treatments for them. “There are over 1,500 diseases known by now, and it is just very difficult to develop therapies for each and every individual rare disease.”
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Other news to note for May 7, 2025

May 7, 2025
Additional early-stage research and drug discovery news in brief, from: Akava Therapeutics, Galmed Pharmaceuticals, Kiora Pharmaceuticals, Mira Pharmaceuticals, Palatin Technologies, Thetis Pharmaceuticals.
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Heart, DNA and ECG
Cardiovascular

Nuevocor draws $45M series B for gene therapy in rare heart disease

May 7, 2025
By Nuala Moran
No Comments
Nuevocor Pte. Ltd. has closed a $45 million series B, enabling it to move lead gene therapy NVC-001 into the clinic in the treatment of an inherited form of cardiomyopathy.
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Cancer

Canwell Biotech discovers new SHP-2 inhibitors

May 7, 2025
Canwell Biotech Ltd. has described tyrosine-protein phosphatase non-receptor type 11 (PTPN11; PTP-2C; SHP-2) inhibitors reported to be useful for the treatment of cancer.
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HIV/AIDS

New HIV integrase inhibitors disclosed in Gilead patent

May 7, 2025
Gilead Sciences Inc. has divulged bridged tricyclic carbamoylpyridone prodrugs acting as HIV integrase inhibitors reported to be useful for the treatment of HIV infection.
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