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Treg cells
Immune

MTX-101 restores CD8 Treg functioning and provides resistance to autoimmunity progression

July 1, 2024
MTX-101 (Mozart Therapeutics Inc.) is a bispecific CD8 Treg modulator that targets CD8 and the KIR2DL family, including KIR2DL1, KIR2DL2 and KIR2DL3, and is being developed for the treatment of CD4-driven autoimmunity and restoring immune balance.
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Red CAR T cell on blue blackground
Cancer

Seed funding at Waypoint Bio supports drug discovery using in vivo spatial pooled screening technology

July 1, 2024
Waypoint Bio has raised $14.5 million in seed funding to support its work pioneering novel cell therapies for solid tumors using in vivo spatial pooled screening technology.
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Endocrine/metabolic

NA-931 reduces body weight and improves metabolic profile in obese mice

July 1, 2024
Biomed Industries Inc. has presented data on its IGF-1/GLP-1/GIP/GCGR quadruple agonist NA-931 for the treatment of obesity and metabolic disorders. The company has discovered a family of IGF-1 metabolites, known as NA-931, and its analogues NA-932 and NA-933, which are referred to as NA-931 compounds.
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Illustration of brain degeneration
Neurology/psychiatric

EAN 2024: Better diagnoses are shared dream of neurodegeneration researchers

July 1, 2024
By Anette Breindl
“Do dreams predict the future?” Abidemi Otaiku asked his audience at the 10th Congress of the European Academy of Neurology, currently being held in Helsinki. Most audience members, being hard-boiled scientists, did not believe they did. But Otaiku, whose work won the award for best clinical abstract at the conference, presented data indicating that in some cases, they can.
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Other news to note for June 28, 2024

June 28, 2024
Additional early-stage research and drug discovery news in brief, from: Cayuga Biotech, Precision Biosciences.
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Cancer

Shenyang Pharmaceutical University discloses high-selectivity PLK4 inhibitors

June 28, 2024
Shenyang Pharmaceutical University has identified serine/threonine-protein kinase PLK4 (STK18) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Hainan Simcere Pharmaceutical discovers FGFR3 inhibitors

June 28, 2024
Hainan Simcere Pharmaceutical Co. Ltd. has patented fibroblast growth factor receptor 3 (FGFR3) inhibitors reported to be useful for the treatment of cancer.
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Cancer

The University of Tokyo presents new peptide compounds with anticancer activity

June 28, 2024
The University of Tokyo has synthesized yaku'amide B analogues reported to be useful for the treatment of cancer.
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Neurology/psychiatric

Takeda Pharmaceutical patents orexin OX2 receptor agonists for narcolepsy

June 28, 2024
Takeda Pharmaceutical Co. Ltd. has discovered orexin OX2 receptor agonists reported to be useful for the treatment of narcolepsy, among others.
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Cancer

Tiger Biotherapeutics describes new KRAS mutant degraders

June 28, 2024
Tiger Biotherapeutics Inc. has disclosed proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase cereblon (CRBN)-binding moiety coupled to a GTPase KRAS (mutant)-binding moiety through a linker.
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