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Musculoskeletal

SR-9243 ameliorates rheumatoid arthritis by modulating glycolysis in macrophages

July 18, 2024
Rheumatoid arthritis (RA) is an autoimmune disease characterized by bone and cartilage destruction, where immune cells such as macrophages, among others, play a crucial role in RA pathogenesis.
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Lungs
Respiratory

Karanjin alleviates sepsis-induced acute lung injury in mice

July 18, 2024
Researchers from Xuzhou Medical University and affiliated organizations have presented data from a study that assessed the protective effect of the natural flavonoid compound karanjin against sepsis-induced acute lung injury (ALI) in mice.
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Colorectal cancer illustration
Cancer

DUSP18 blockade induces antitumor immune activity in colorectal cancer

July 18, 2024
Tumor cells use metabolic reprogramming for their survival and to fuel and boost their proliferation. Only 15% of patients with colorectal cancer (CRC) benefit from immune checkpoint blockade therapy, mainly due to tumor microenvironment changes to promote CD8+ T-cell exhaustion and inactivation allowing tumor cells to escape from immunity.
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3D cross-section illustration of muscle anatomy
Musculoskeletal

FDA approves IND for Myopaxon in Duchenne muscular dystrophy

July 18, 2024
Myogenica Inc., a University of Minnesota startup company, has obtained IND approval from the FDA for Myopaxon, an induced pluripotent stem cell (iPSC)-derived muscle stem cell product to regenerate skeletal muscle. A planned study will evaluate intramuscular injections of Myopaxon in non-ambulatory adult patients with Duchenne muscular dystrophy.
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Cancer

Inhibiting epigenetic regulator blocks liver cancer development

July 18, 2024
Transposable elements (TEs) are DNA sequences involved in the epigenetic regulation of tumors. KDM1A is an epigenetic regulator overexpressed in liver cancer that suppresses the methylation of histone H3 Lys4 (H3K4) in liver-TEs and as a result, HNF4A expression is silenced and hepatocellular carcinoma (HCC) growth is promoted.
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3D representation of tumor
Cancer

Inhibition of mutant IDH1 restores solid tumor immune sensitivity

July 18, 2024
By Xavier Bofill Bruna
Mutations in the metabolic enzyme isocitrate dehydrogenase 1 (IDH1) induce tumorigenesis due to generation of the oncometabolite (R)-2-hydroxyglutarate (R-2HG). A hallmark of solid tumors carrying mutations in IDH1 is immune evasion by T-cell exclusion and altered epigenetic state. Researchers from the Center for Cancer Research, Massachusetts General Hospital have published a study in Science on July 12, 2024, in which they demonstrate that inhibiting mutant IDH1 restored antitumoral immunity.
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Other news to note for July 17, 2024

July 17, 2024
Additional early-stage research and drug discovery news in brief, from: Flag Therapeutics, Io Therapeutics, Seyltx, Zailab.
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Medical illustration showing different layers of a human bone
Endocrine/metabolic

Brain hormone makes strong contribution to bones

July 17, 2024
By Coia Dulsat
Researchers from the University of California San Francisco (UCSF) have found that CCN3, a hormone secreted by neurons in the brain, is responsible for maintaining bone strength during lactation.
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Cancer

University of Regensburg discovers new FLT3 inhibitors for AML

July 17, 2024
University of Regensburg has described water-soluble FLT3 (FLK2/STK1) inhibitors and their prodrugs reported to be useful for the treatment of acute myeloid leukemia (AML).
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Diagnostics

New P2X4 antagonists disclosed in Universität Bonn patent

July 17, 2024
Universität Bonn has divulged P2X purinoceptor 4 (P2RX4; P2X4) antagonists reported to be useful as diagnostics and for the treatment of pain, inflammation, cancer, stroke, multiple sclerosis, atherosclerosis and obesity.
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