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BioWorld - Wednesday, December 31, 2025
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Art concept for drug research
Inflammatory

Series B financing at Trex Bio supports immunology pipeline development

Nov. 14, 2024
Trex Bio Inc. has closed an oversubscribed $84 million series B financing round to support development of its pipeline of novel therapies that modulate the immune system to restore human tissue immune homeostasis.
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Immuno-oncology

Bolt presents immune-stimulating antibody-drug conjugate

Nov. 14, 2024
Claudin (CLDN) 18.2 is a transmembrane tight junction protein overexpressed in multiple cancers, including gastric, esophageal and pancreatic cancers.
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Endocrine/metabolic

Islet-targeted gene therapy RJVA-001 leads to durable weight loss in obese mice

Nov. 14, 2024
Researchers from Fractyl Health Inc. presented preclinical data for RJVA-001, a novel pancreatic gene therapy.
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Dermatologic

Enveda advances ENV-294 into clinic for atopic dermatitis

Nov. 14, 2024
Enveda Therapeutics Inc. has received U.S. IND clearance and advanced into phase I trials with ENV-294, its naturally derived anti-inflammatory.
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3D rendering conceptualizing theranostics
Cancer

Artbio and 3B Pharmaceuticals to advance α-radioligand therapy for solid tumors

Nov. 14, 2024
Artbio Inc. and 3B Pharmaceuticals GmbH have signed a worldwide, exclusive license and research agreement to develop an advanced preclinical stage first-in-class peptide α-radioligand therapy for the treatment of solid tumors.
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Adenovirus cells
Neurology/psychiatric

Preclinical data on SPK-10001 AAV-based gene therapy released

Nov. 14, 2024
Spark Therapeutics Inc. has presented preclinical data on SPK-10001, an engineered adeno-associated virus (AAV).
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Heart and DNA
Cardiovascular

Avidity Biosciences unveils new cardiology development candidates

Nov. 14, 2024
Avidity Biosciences Inc. has announced two new precision cardiology development candidates targeting rare genetic cardiomyopathies. AOC-1086 targets phospholamban (PLN) cardiomyopathy and AOC-1072 targets protein kinase AMP-activated noncatalytic subunit γ2 (PRKAG2) syndrome.
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X/Y chromosomes
Healing the health divide

The science of gender-based medicine: many reasons, many manifestations

Nov. 14, 2024
By Anette Breindl
At the BioFuture 2024 conference held in New York in November, Seema Kumar, the CEO of Cure, described women’s health as something that has been directed at the “bikini area.” That “bikini” bias extended to both diseases and their causes – women’s health covered the breasts and reproductive system, and its causes were hormonal. Both concepts are far too narrow.
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Group of multigenerational, multiracial women

Healing a health divide (that’s long overdue)

Nov. 14, 2024
By Lynn Yoffee
It’s difficult to fathom that the health of half the world’s population is underserved. But it’s a hard truth. There are many conditions that disproportionately impact women. Other conditions and diseases affect women in different ways than men. Decades of research excluding women from clinical trials and investment decisions in male-dominated board rooms have ignored these facts. Though an increasing number of women are now managing investments and driving the research, it’s all still woefully behind. In BioWorld’s new report, Healing the health divide, we’ve highlighted the disparities.
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John Mendlein, executive chairman and interim CEO, Vesalius
Neurology/psychiatric

Vesalius-GSK $650M pact: Targeting Parkinson’s root causes

Nov. 13, 2024
By Karen Carey
More than two years since emerging from stealth, Vesalius Therapeutics Inc. signed its first major pharma deal with GSK plc. Worth up to $650 million and possibly more if an option is exercised, the multitarget alliance aims to discover and develop novel treatments for Parkinson’s disease and another neurodegenerative indication.
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