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BioWorld - Tuesday, January 13, 2026
Breaking News: BioWorld Science 2025 Year in ReviewBreaking News: BioWorld 2025 Year in ReviewBreaking News: BioWorld MedTech 2025 Year in ReviewBreaking News: Trump administration impacts continue to roil the life sciences sector
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Cancer

MBT-C101, a selective and potent HSP90 chaperone-mediated degrader of PI3Kα

Nov. 18, 2024
MBT-C101 is a selective, potentially first-in-class potent HSP90 chaperone-mediated degrader of PI3Kα, for the treatment of breast cancer. It was developed by Magicbullet Therapeutics Inc. using the company’s Chaperone-mediated Degrader (CM-Degrader) platform.
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Art concept for molecular glue degradation
Immuno-oncology

Plexium provides details on preclinical activity of IKZF2 molecular glue degrader

Nov. 18, 2024
The transcription factor IKZF2 is a marker of highly suppressive regulatory T cells (Tregs). When IKZF2 is degraded, Tregs become effector-like T cells leading to increased antitumor immune response in the tumor microenvironment.
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Immuno-oncology

Trogenix emerges from stealth with focus on aggressive cancers

Nov. 18, 2024
Trogenix Ltd. has emerged from stealth with a focus on treating cancer through viral immunotherapy. The company was founded as a spinout from the University of Edinburgh last year.
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3D illustration showing tumor inside prostate gland and closeup view of cancer cells
Cancer

NCI grant supports Cancer Targeted Technology’s prodrug for prostate cancer

Nov. 18, 2024
Cancer Targeted Technology LLC has been awarded the phase I portion ($400,000) of a fast track phase I/II ($2.4 million) Small Business Innovation Research (SBIR) grant by the National Cancer Institute (NCI) to develop CTT-2274 to treat metastatic prostate cancer.
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Immuno-oncology

Elpiscience designs fusion protein consisting of NKG2A antibody conjugated to IL-2 mutant

Nov. 18, 2024
Researchers from Elpiscience Biopharmaceuticals Inc. discussed the discovery and preclinical characterization of a novel NKG2A antibody-IL-2 mutant fusion protein – ES-015.129 – being developed as cancer immunotherapy.
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Photo of older woman holding hand that's colored red
Musculoskeletal

Research supports CCN1 as a therapeutic target in rheumatoid arthritis

Nov. 18, 2024
Previous studies reported that cellular communication network factor 1 (CCN1) is overexpressed in the endothelial cells and synovial tissue of patients with rheumatoid arthritis (RA). French researchers have now investigated the effects of inhibiting CCN1 in two murine models of RA with the aim of proposing CCN1 as a potential therapeutic target in RA.
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Diagram of how cells take up glucose from the stomach and insulin from the pancreas
Endocrine/metabolic

Astrazeneca exercises option for type 1 diabetes Treg cell therapy program with Quell

Nov. 18, 2024
Astrazeneca plc has selected a candidate to progress under its type 1 diabetes regulatory T cell (Treg) therapy program with Quell Therapeutics Ltd. The company has exercised its exclusive option to license the therapy for further development and commercialization, resulting in a milestone payment to Quell of $10 million.
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Immuno-oncology

Exelixis publishes characterization of anti-TF conjugate with strong antitumor efficacy

Nov. 18, 2024
Researchers from Exelixis Inc. described the preclinical characterization of XB-002, an antibody-drug conjugate consisting of a monoclonal antibody recognizing a tissue factor (TF) epitope that does not interfere with factor VII binding.
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DNA on digital background
Drug design, drug delivery & technologies

‘Evo’ AI can design complete genomes

Nov. 18, 2024
By Mar de Miguel
The development of new machine learning tools like Alphafold and Rfdiffusion has allowed scientists to predict the structure of proteins and design them for drug discovery purposes, among other uses. Now, scientists at the Arc Institute have created Evo, an AI model that generates DNA sequences and estimates their interaction with other molecules at single-nucleotide resolution, scalable to an entire genome.
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Female healthcare professional holding dollar sign
Women's health

Despite women’s health inroads, lackluster funding impedes progress

Nov. 15, 2024
By Karen Carey
While women make up half the world’s population and own two out of every five businesses, there are substantial knowledge gaps about conditions affecting their health – mostly due to decades of research excluding women from clinical trials and investment decisions.
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