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Tree in the shape of human head losing leaves
Neurology/Psychiatric

Study supports TIM-3 as therapeutic target for Alzheimer’s disease

March 15, 2024
Recent studies have identified HAVCR2, which encodes immune checkpoint molecule TIM-3 (T-cell immunoglobulin mucin receptor 3), as a risk gene for late-onset Alzheimer’s disease (AD).
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Coronal plane slices of the brain comparing normal to Alzheimer’s.
Neurology/Psychiatric

KCNJ10 identified as a target in Alzheimer’s disease

March 15, 2024
Deep molecular profiling of cell types in the brain is needed to uncover the mechanisms behind neurodegeneration.
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Art concept for tumor
Cancer

VIO-01, a pan-DDR decoy with efficacy in HRD or HRP tumor models

March 15, 2024
Preclinical data were recently presented for VIO-01 (Valerio Therapeutics SA), a first-in-class pan-DNA damage response (DDR) decoy being developed for the treatment of cancer.
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Woman and 3D brain
Neurology/Psychiatric

Ono and Sibylla collaborate in neurological disorders

March 15, 2024
Ono Pharmaceutical Co. Ltd. has entered into a collaboration agreement with Sibylla Biotech SpA to generate novel drug candidates for neurological disorders. Under this collaboration, Sibylla will utilize its proprietary Pharmacological Protein Inactivation by Folding Intermediates Targeting (PPI-FIT) protein degradation technology platform.
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Neurology/Psychiatric

Targeting Kv1.3 reduces neuroinflammation

March 15, 2024
Kv1.3 is a voltage-gated potassium channel that plays a crucial role in neuroinflammation and neurodegeneration in Parkinson’s disease and other disorders. Preclinical studies have shown that Kv1.3 inhibition confers neuroprotection against neurodegenerative disorders.
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Doctor pointing at liver
Substance Use & Poisoning

UAMC-3203 lessens acetaminophen-induced liver toxicity, study suggests

March 15, 2024
Acetaminophen overdose is still a major cause of liver toxicity (acute liver failure, ALI) in Western countries. It occurs by accumulation of the toxic metabolite NAPQI and the subsequent mitochondrial oxidative stress mediated by pJNK translocation to the mitochondria.
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Test tube, dropper
Neurology/Psychiatric

New UC Berkeley Molecular Therapeutics Initiative seeks to accelerate drug discovery

March 15, 2024
The University of California, Berkeley has announced the launch of the UC Berkeley Molecular Therapeutics Initiative (MTI) designed to accelerate drug discovery. The aim is to bridge fundamental research in rare neurological and metabolic diseases with drug discovery to identify and accelerate novel therapeutic modalities into the clinic.
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HIV/AIDS

AM-80 enhances NK cytotoxicity against HIV-infected CD4+ T cells

March 15, 2024
Retinoids are derivatives of vitamin A that target the retinoid receptors and induce antiproliferative effects and cell death. George Washington University has tested a series of different retinoids, including alitretinoin, tazarotene and AM-80, also known as tamibarotene, for their efficacy against HIV-infected CD4+ T cells regarding their ability to enhance the cytotoxic effect of NK cells.
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Art concept for neurotransmission
Neurology/Psychiatric

Don’t panic, generalized fear is a switch of neurotransmitters

March 15, 2024
By Mar de Miguel
Mapping brain circuits and studying the neural signals that are activated during post-traumatic stress could provide an answer to the generalized fear associated with this disorder. Scientists at the University of California, San Diego have identified a change in the expression of neurotransmitters as an adaptive response that could trigger this effect.
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Neurology/Psychiatric

Xgene gains Australian clearance for phase I study of XG-2002

March 14, 2024
Xgene Pharmaceutical Pty Ltd., a subsidiary of Xgene Pharmaceutical Co. Ltd., has received approval in Australia to initiate a phase I trial of the selective TRPM8 blocker XG-2002 (RQ-00434739).
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