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Ocular

Roche identifies MMP-9 inhibitors for dry eye

June 10, 2025
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have patented 5-[2,7-diazaspiro[3.5]nonan-7-yl]-5-[4-phenoxyphenyl]hexahydropyrimidine-2,4,6-trione derivatives acting as matrix metalloproteinase-9, (MMP-9) inhibitors potentially useful for the treatment of dry eye.
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Gastrointestinal

17β-HSD13 inhibitors described in Astrazeneca patent

June 10, 2025
Astrazeneca AB has reported the identification of 17β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17β-HSD13) inhibitors reported to be useful for the treatment of nonalcoholic steatohepatitis (NASH; MASH), among others.
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Endocrine/metabolic

Lilly patents RXFP1 agonists

June 10, 2025
An Eli Lilly & Co. patent describes new relaxin receptor 1 (RXFP1; LGR7) agonists potentially useful for the treatment of diabetes, stroke, atherosclerosis and more.
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Targeted cancer cell
Cancer

Non-coding RNA has potential as marker, target in liver cancer

June 10, 2025
No Comments
Hepatocellular carcinoma is the most frequent form of primary liver cancer, and most patients are diagnosed when the disease is already advanced and therefore prognosis is poor despite available treatments. Understanding what contributes to the malignancy may help develop effective treatments.
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Cancer

Mitotic motor protein Eg5 inhibitor Arry-520 to treat gastric cancer

June 10, 2025
No Comments
Gastric cancer, which is the fifth most frequent cancer globally and the third most frequent cause of cancer-related deaths, can be managed relatively well with existing therapies. Advanced gastric cancer, in contrast, is more difficult to manage.
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Acute myeloid leukemia
Cancer

KPNB1 targeting shows antileukemic effects

June 10, 2025
No Comments
Acute myeloid leukemia (AML) is the most prevalent hematological malignancy. Despite advances in the field, about 60% of patients with AML do not survive >5 years. It is an urgent need to identify novel therapeutic targets for managing AML.
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Kidneys
Inflammatory

Novel STING antagonist shows robust anti-inflammatory activity

June 10, 2025
No Comments
Persistent activation of the stimulator of interferon genes (STING), resulting from aberrant metabolism or mutations in STING1, can lead to inflammatory damage and autoimmune diseases. Therefore, inhibiting STING activity may offer therapeutic potential for treating these disorders.
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Neurology/psychiatric

Solve FSHD and Modalis collaborate on treatment for muscular dystrophy subtype

June 10, 2025
No Comments
Solve FSHD and Modalis Therapeutics Corp. have established a strategic collaboration to develop an innovative therapy for facioscapulohumeral muscular dystrophy (FSHD).
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Gastrointestinal

Kv1.3 induces alcohol-related liver disease

June 10, 2025
No Comments
Researchers have investigated the role of the voltage-dependent potassium channel Kv1.3 in vivo in a murine model of ethanol-exposed alcohol-related liver disease (ALD).
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Female hands holding heart on cardiogram
Cardiovascular

Nuevocor’s NVC-001 cleared to enter clinic for dilated cardiomyopathy

June 10, 2025
No Comments
Nuevocor Pte. Ltd. has obtained IND clearance by the FDA for NVC-001, an AAV-based gene therapy.
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