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Neurology/psychiatric

Viva Star Biosciences discloses new NLRP3 inflammasome inhibitors

June 25, 2025
Viva Star Biosciences (Suzhou) Co Ltd. and Viva Star Biosciences (US) Inc. have patented new NLRP3 inflammasome inhibitors reported to be useful for the treatment of neurodegeneration, metabolic diseases, inflammatory disorders, cancer and genetic disorders.
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Immune

Rubedo Life Sciences patents new Bcl-xl inhibitors

June 25, 2025
Work at Rubedo Life Sciences Inc. has led to the development of Bcl-2-like protein 1 (Bcl-xl; Bcl-X; BCL2L1) inhibitors acting as senolytic agents and reported to be useful for the treatment of autoimmune disease, cancer, cardiovascular disorders, cognitive disorders, diabetes, inflammatory, metabolic and neurological disorders, among others.
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Brain cancer illustration
Immuno-oncology

New anti-CD99 antibody shows preclinical promise for diffuse midline glioma treatment

June 25, 2025
No Comments
Diffuse midline gliomas (DMGs) are pediatric brain tumors with a very dismal prognosis since less than 5% of patients survive 2 years after diagnosis. Radiotherapy remains the standard treatment for DMG, and several combination chemotherapies and single-agent target therapies are currently being explored.
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Leukemia illustration
Cancer

Rgenta’s RGT-61159 shows promise for MYB-expressing cancers

June 25, 2025
No Comments
MYB is an oncogenic transcription factor that is often aberrantly expressed in hematologic malignancies, mostly in acute myeloid leukemia (AML). Rgenta Therapeutics Inc. recently presented data for RGT-61159, a potent and selective MYB inhibitor compound that demonstrated cell killing across a panel of MYB-overexpressing leukemic cell lines.
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Immuno-oncology

Adenovirus-infected CAR T cells expressing IL-15 to treat glioblastoma

June 25, 2025
No Comments
Glioblastoma is the most frequent and aggressive primary brain cancer in adults, and patients can expect to live shorter than 2 years, regardless of therapy. The cancer can be treated with CAR T cells, but many patients develop resistance because tumors mutate or delete the antigens recognized by the T cells, while the tumor microenvironment suppresses T-cell activity.
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Illustration of man holding magnifying glass to human body model showing muscle anatomy
Neurology/psychiatric

Cure Rare Disease completes pre-IND meeting for limb girdle muscular dystrophy gene therapy program

June 25, 2025
No Comments
Cure Rare Disease has successfully completed a pre-IND meeting with the FDA regarding its investigational gene therapy program for limb-girdle muscular dystrophy type 2I/R9 (LGMDR9).
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Illustration of hole in vessel wall with repair process in progress
Hematologic

SV-003 restores coagulation in the preclinical setting

June 25, 2025
No Comments
Bispecific antibodies mimicking coagulation factor VIIIa (FVIIIa) have yielded successful results in the treatment of hemophilia A, but there remain some issues in regard to their production.
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Female scientist looking through microscope
Endocrine/metabolic

Supercede’s SPCD-4-79 demonstrates preclinical efficacy in DIO mice

June 25, 2025
No Comments
Supercede Therapeutics Inc. has released preclinical efficacy data on its small-molecule inhibitor of the Activin receptor type II (ACTRII) to treat obesity.
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T cells
Immune

Cue Biopharma holds pre-IND meeting with FDA for lead autoimmune asset

June 25, 2025
No Comments
Cue Biopharma Inc. has received pre-IND feedback from the FDA to discuss the proposed development plan for CUE-401, its lead autoimmune asset. Based on FDA feedback, the company intends to file an IND pending completion of final IND-enabling studies.
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Cancer

New CAIX-targeting 68Ga/177Lu theranostic pair for clear cell renal cell carcinoma

June 25, 2025
No Comments
At the recent meeting of the Society of Nuclear Medicine and Molecular Imaging, Chinese Academy of Medical Sciences and Peking Union Medical College scientists co-presented a carbonic anhydrase IX (CAIX)-targeting 68Ga/177Lu theranostic pair for clear cell renal cell carcinoma (ccRCC) and its preclinical evaluation.
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