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Free access to BioWorld coronavirus articles

June 6, 2025
The articles in this collection are from BioWorld’s ongoing coverage of the COVID-19 coronavirus pandemic. They are available for free with registration. Note that we have added three critical tables, which are continuously updated:

Vaccines and therapeutics in development
Diagnostics with U.S. FDA emergency use authorization
Clinical trials of biopharma products affected by COVID-19
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Signify Daniel-Siegwart and RA Session II
Drug design, drug delivery & technologies

Signify Bio’s $15M round advances in situ protein therapeutics

June 6, 2025
By Karen Carey
No Comments
Turning the human body into a biofactory of precision protein therapeutics is the focus of newly launched Signify Bio, which emerged with an oversubscribed $15 million initial financing to advance three platforms with broad potential across therapeutic areas.
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Woman and molecular overlay
Aging

Taurine aging biomarker story gets more complicated

June 6, 2025
By Xavier Bofill Bruna
No Comments
A publication based on longitudinal and cross sectional data and led by researchers at the U.S. NIH’s National Institute on Aging published on June 5, 2025, in Science has stated that the impact of taurine supplementation at delaying aging or treating aging-related conditions is context-dependent, and that the circulating levels of taurine are impacted by factors unique to each individual rather than declining with age. To qualify taurine as a true marker of aging, it should change with age across diverse populations over time and ideally supported by longitudinal data.
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Holiday notice

June 6, 2025
In accordance with the publishing schedule, BioWorld Science will not be published on Monday, June 9, 2025.
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Nephrology

Vertex Pharmaceuticals discovers new PKD1 correctors

June 6, 2025
Vertex Pharmaceuticals Inc. has described polycystin-1 (PKD1) (mutant) correctors reported to be useful for the treatment of autosomal dominant polycystic kidney disease.
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Gastrointestinal

New 17β-HSD13 inhibitors disclosed in Astrazeneca patents

June 6, 2025
Astrazeneca AB has divulged 17β-hydroxysteroid dehydrogenase 13 (HSD17B13; 17β-HSD13) inhibitors reported to be useful for the treatment of alcoholic liver disease, liver fibrosis, cirrhosis, hepatic steatosis, liver inflammation, hepatitis C virus (HCV) infection and liver cancer (hepatocellular carcinoma).
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Neurology/psychiatric

Merck Sharp & Dohme describes new HCN1 and HCN2 blockers

June 6, 2025
Merck Sharp & Dohme LLC has identified compounds acting as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1) and/or 2 (HCN2) blockers reported to be useful for the treatment of neuropathic pain, tinnitus, psychiatric and neurological disorders.
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Infection

Gilead Sciences divulges new compounds to treat herpes virus infection

June 6, 2025
Gilead Sciences Inc. has synthesized indoline compounds acting as DNA helicase-primase complex (human herpes simplex virus) and viral replication inhibitors reported to be useful for the treatment of herpes virus infection.
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Dermatologic

Biogen patents new TYK2 inhibitors

June 6, 2025
Biogen Inc. has disclosed non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of stroke, psoriasis, arthritis, pain, silicosis, alopecia and more.
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Elderly woman holding illustration of brain with missing puzzle piece
Neurology/psychiatric

Grant supports Mindimmune’s development of MITI-101 for Alzheimer’s disease

June 6, 2025
No Comments
Mindimmune Therapeutics Inc. has been awarded a grant by Rhode Island Life Science Hub to accelerate preclinical development work on MITI-101 for the treatment of mild to moderate Alzheimer’s disease. The award will accelerate development work needed to start first-in-human studies.
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