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Cancer

EMA’s COMP recommends orphan drug designation for Hemispherian’s GLIX-1 for glioma

June 6, 2025
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The EMA’s Committee for Orphan Medicinal Products (COMP) has issued a positive opinion recommending European orphan drug designation for Hemispherian AS’s GLIX-1 for the treatment of glioma.
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Man with respiratory issues
Respiratory

Seyltx enters option agreement to in-license Neurop’s GluN2B antagonists for chronic cough

June 6, 2025
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Seyltx Inc. has entered into an option agreement with Neurop Inc. for a portfolio of novel GluN2B antagonists. The compounds include NP-10679, which has completed phase I, and seven preclinical candidates.
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Illustration of brain receptors with their neurotransmitters
Neurology/psychiatric

New GluN1/GluN3A NMDA receptor inhibitors based on AI

June 6, 2025
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Scientists at Shanghai Tech University have used the scaffold-hopping artificial intelligence model Geminimol to identify N-methyl-D-aspartate (NMDA) receptor ligands that show selectivity and specificity. The researchers found that GM-10 could be a potent inhibitor of the GluN1/GluN3A subunits of the NMDA receptor, demonstrating the utility of this technique to develop new drugs.


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Neurology/psychiatric

Solvonis completes synthesis of development candidates for SVN-SDN-014 program

June 6, 2025
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Solvonis Therapeutics plc has completed synthesis of development candidates for its SVN-SDN-014 program, a novel series of serotonin, dopamine and noradrenaline modulators.
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Structural model of dengue virus.
Immune

Immunoprecise Antibodies discovers highly conserved epitope across all four dengue virus serotypes

June 6, 2025
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Immunoprecise Antibodies Ltd. has discovered a highly conserved epitope across all four dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) using its proprietary Lensai platform powered by its Hyft technology.
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Neurology/psychiatric

Chinese researchers disclose a selective, non-irritant TRPA1 agonist for pain relief

June 6, 2025
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Using agonists to desensitize the homotetrameric transient receptor potential ankyrin 1 (TRPA1) channel is a validated strategy for pain relief.
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Close up image of shoulder and back with severe urticaria or hives
Dermatologic

Aqilion reports results for TAK1 program in skin inflammation studies

June 6, 2025
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Aqilion AB has released promising results from new studies with molecules from the company’s lead series within the TAK1 program, demonstrating a strong disease-modifying effect in a well-established model of skin inflammation.
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Drug capsule spilling onto brain
Neurology/psychiatric

Casma nominates TRPML1 agonist as development candidate

June 6, 2025
No Comments
Casma Therapeutics Inc. has nominated its first development candidate, CSM-101, a first-in-class TRPML1 agonist. CSM-101 is being developed for the treatment of Gaucher’s disease patients with Parkinson’s disease, with the potential to expand into GBA-associated Parkinson’s disease and broader Parkinson’s disease populations.
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Trump administration impacts continue to roil the life sciences sector

June 5, 2025
Cancer

Kumquat Biosciences discovers new GTPase KRAS wild-type and mutant inhibitors

June 5, 2025
Kumquat Biosciences Inc. has described compounds acting as GTPase KRAS wild-type and mutant inhibitors reported to be useful for the treatment of cancer.
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