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Transmission electron micrograph of HIV-1 virus particles
HIV/AIDS

IAS 2025: Cheat, parasitize, break the virus – fresh ideas fuel HIV research

July 18, 2025
No Comments
There is still no effective vaccine or cure for HIV. Scientists are considering options ranging from longer-term antiretroviral therapy (ART) that space out injections by several years to long-lasting pre-exposure prophylaxis (PrEP) that acts as a vaccine while immunization is achieved. What else can be done? The “Innovations in HIV virology: Translating discoveries into novel therapies” symposium in basic science at the 13th IAS Conference on HIV Science (IAS 2025), which took place from July 13 to 17, 2025, in Kigali, Rwanda, showcased some of the new ideas that the scientific community are developing.
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Carotid ultrasound
Aging

UK Biobank project complete, supports research with 100,000 scans

July 17, 2025
By Nuala Moran
No Comments
After a 10-year project and a £60 million (US$80 million) investment, the UK Biobank has completed the whole body scans of 100,000 volunteers and is making the 1 billion images available for researchers worldwide.
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Cancer

GSK prepares new compounds for treatment of cancer

July 17, 2025
GSK plc has patented compounds potentially useful for the treatment of cancer.
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Inflammatory

AC Immune patent discloses new NLRP3 inflammasome inhibitors

July 17, 2025
AC Immune SA has synthesized new heterocyclic modulators acting as NLRP3 inflammasome inhibitors. As such, they are reported to be potentially useful for the treatment of asthma, atherosclerosis, obesity, gout, cryopyrin-associated periodic syndromes, nonalcoholic fatty liver disease (NAFLD), Parkinson’s and Alzheimer’s disease, among others.
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Endocrine/metabolic

VDAC1 inhibitors reported in Abarceo patent

July 17, 2025
Abarceo AB has developed new voltage-dependent anion-selective channel protein 1 (VDAC1) inhibitors reported to be useful for the treatment of diabetes type 1 and 2.
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Cancer

Merck Sharp & Dohme discovers new PTPN1 and PTPN2 inhibitors

July 17, 2025
A recent Merck Sharp & Dohme LLC patent details new substituted isoquinoline derivatives acting as tyrosine-protein phosphatase non-receptor type 1 (PTPN1; PTP-1B) and/or PTPN2 (TCPTP) inhibitors potentially useful for the treatment of cancer.
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Cancer

Childrens Medical Center patents new gasdermin-D activators

July 17, 2025
Work at Childrens Medical Center Corp. has led to the identification of new gasdermin-D (GSDMD) activators reported to be useful for the treatment of cancer.
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3D illustration of tumor
Cancer

PROTAC-mediated DDR1 degradation unlocks tumor immunity

July 17, 2025
No Comments
Discoidin domain receptor tyrosine kinase 1 (DDR1) contributes to tumor progression by promoting the alignment and densification of collagen fibers within the extracellular matrix (ECM), thereby facilitating the development of an immune-excluded tumor microenvironment (TME).
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Diagram of how cells take up glucose from the stomach and insulin from the pancreas
Endocrine/metabolic

An agonist of the BMP receptor to stimulate new β-cell formation in diabetes

July 17, 2025
No Comments
Stimulating the production of β cells in the pancreas of individuals with type 1 diabetes may be a way to renormalize their glucose metabolism. Researchers from Spain and the U.S. may have moved one step closer to this goal by stimulating formation of new β cells in the pancreas of a mouse model of diabetes using the cyclic peptide THR-123, which binds and activates the receptor for bone morphogenetic protein (BMP).
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Biomarkers

Study unveils TNFRSF9 as a marker of abdominal aortic aneurysm

July 17, 2025
No Comments
Abdominal aortic aneurysm is a life-threatening cardiovascular disease characterized by chronic inflammation and irreversible dilatation of the abdominal aorta and is asymptomatic at the early stages of the disease, with diagnosis usually relying on imaging techniques and surgery being the main approach for treating it.
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