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BioWorld - Sunday, June 14, 2026
Home » Topics » Science » Drug design, drug delivery and technologies

Drug design, drug delivery and technologies
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Colorized transmission electron micrograph of yellow fever virus particles.
Infection

Preclinical treatment neutralizes yellow fever virus

April 5, 2023
Two neutralizing monoclonal antibodies isolated from volunteers vaccinated against the yellow fever virus controlled the viremia and prevented severe disease and death in hamsters and primates.
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Drug Design, Drug Delivery & Technologies

Designer bacteria PROT3ECTs against inflammation in IBD mouse model

April 4, 2023
By Subhasree Nag
A team of researchers from Harvard University has developed a suite of Escherichia coli Nissle 1917 (EcN), named PRObiotic type 3 secretion E. coli therapeutic (PROT3ECT), engineered to secrete a TNF-α nanobody directly into the gut to reduce inflammation in a chemically induced inflammatory bowel disease (IBD) mouse model.
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Futuristic medicine research illustration with petri dishes and pipette
Drug Design, Drug Delivery & Technologies

Gandeeva and Moderna enter research collaboration using AI-enabled cryogenic electron microscopy

March 31, 2023
Gandeeva Therapeutics Inc. has entered into a research collaboration with Moderna Inc. to...
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Scanning electron microscope image of cancer cells killed by programmed Photorhabdus virulence cassettes
Drug Design, Drug Delivery & Technologies

Molecular syringe could revolutionize therapeutic protein delivery

March 30, 2023
By Helen Albert
A research team based at MIT and Harvard has engineered a bacterial injection system to precisely deliver proteins to human cells. This work, published online March 29, 2023, in Nature, is important as while more and more molecular therapies are being developed, off-target effects are always a concern and precise targeting of cells and tissues can still be a challenge.
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DNA, drug development concept art.
Drug Design, Drug Delivery & Technologies

Moderna and Generation Bio collaborate to develop nonviral genetic medicines

March 24, 2023
Moderna Inc. and Generation Bio Co. have entered into a strategic collaboration to combine Moderna’s biological and technical expertise...
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Drug research
Drug Design, Drug Delivery & Technologies

Charm Therapeutics and Bristol Myers Squibb establish drug discovery collaboration

March 21, 2023
Charm Therapeutics Ltd. has entered into a strategic discovery collaboration with Bristol Myers Squibb Co. for the identification and optimization of compounds against Bristol Myers Squibb's selected targets.
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3D concept image of nanoparticle layers
Immuno-oncology

Talem Therapeutics collaborates with Libera Bio to develop novel antibodies for use with MPN delivery

March 16, 2023
Talem Therapeutics LLC, an independently...
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Concept art for RNA interference, gene silencing.
Neurology/Psychiatric

Switch Therapeutics launches with focus on conditionally activated siRNA molecules

March 14, 2023
Switch Therapeutics Inc. has announced its launch following US$52 million of financing. The company was founded on the premise of a new type of RNA medicine that integrates nucleic acid nanotechnology and RNA interference (RNAi) science.
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DNA illustration
Drug Design, Drug Delivery & Technologies

Epic Bio achieves persistent gene activation using GEMS platform

March 14, 2023
Epic Bio (Epicrispr Biotechnologies Inc.) has presented new data demonstrating the achievement of persistent gene activation using its Gene Expression Modulation System (GEMS) platform.
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Photomicrograph of bone marrow aspirate showing myeloblasts of acute myeloid leukemia
Cancer

A new dual strategy for acute myeloid leukemia

March 13, 2023
By Mar de Miguel
Two molecules that affected the cell cycle only of acute myeloid leukemia (AML) cells could be used as a clinical strategy against this pathology. Scientists at Memorial Sloan Kettering Cancer Center and Harvard University have discovered that DEG-35 and DEG-77 arrested the cell cycle and promoted cell differentiation and apoptosis in these cells.
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