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BioWorld - Tuesday, February 3, 2026
Home » Topics » Science » New compound

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3D rendering conceptualizing theranostics
Diagnostics

[67Cu]EB-TATE demonstrates efficacy in cellular GP-NET models

Oct. 27, 2022
Researchers from the University of Saskatchewan have developed a novel theranostic candidate, [67Cu]EB-TATE, as an alternative to [177Lu]DOTATATE, for the imaging of gastroenteropancreatic neuroendocrine tumors (GEP-NET). EB-TATE, which is a derivative of octreotate with evans blue (EB), was radiolabeled with electron linear accelerator-produced 67CuCl2.
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Cancer cell targeted in crosshairs
Cancer

F3-8-60, pan-RAS inhibitor with efficacy in malignant peripheral nerve sheath tumors and pancreatic cancer

Oct. 26, 2022
Researchers from Qualigen Therapeutics Inc. and University of Louisville presented the discovery and preclinical evaluation of a novel pan-RAS inhibitor...
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Antibodies attacking SARS-CoV-2 virus
Infection

Discovery of novel broadly neutralizing MAb against SARS-CoV-2

Oct. 25, 2022
Researchers from Emory University have discovered a novel broadly neutralizing SARS-CoV-2 antibody, 002-S21F2, being developed as a potential anti-coronavirus therapeutic.
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Prostate cancer cells
Diagnostics

Peptide substitution stabilizes GRPR antagonist while maintaining its biological features

Oct. 21, 2022
The suboptimal metabolic stability of radiolabeled gastrin-releasing peptide receptor (GRPR) antagonists has been a hindering factor of these promising theranostic candidates for prostate cancer. Uppsala University researchers have recently reported the development of [111In]DOTAGA-PEG-2-SAR11-RM-26, after replacement of Gly11 by Sar11 in the peptidic chain.
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Neurology/Psychiatric

Novel mPGES-1 inhibitor demonstrates neuroprotective effects in models of PD

Oct. 21, 2022
mPGES-1 is overexpressed in the dopaminergic neurons of the substantia nigra pars compacta of post-mortem brain tissue from patients with Parkinson’s disease (PD) as well as in 6-hydroxydopamine (6-OHDA)-injected PD mice.
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PET imaging
Diagnostics

Development of heterobivalent radiotracer targeting PSMA and GRPR

Oct. 21, 2022
Researchers have detailed the development and preclinical characterization of a novel heterobivalent radiotracer targeting prostate-specific membrane antigen (PSMA) and the gastrin-releasing peptide receptor (GRPR).
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HIV drugs
HIV/AIDS

ZLM-66, a promising new orally active biphenyl-containing doravirine analogue

Oct. 19, 2022
Researchers have discovered biphenyl-substituted pyridine derivatives of doravirine to be developed as novel HIV therapeutics.
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Prostate cancer cells
Diagnostics

Researchers develop bispecific PSMA/FAP radiotracers for prostate cancer imaging

Oct. 19, 2022
At the recent European Association of Nuclear Medicine meeting in Barcelona, researchers from the British Columbia Cancer Research Institute and the University of British Columbia reported the development and preclinical evaluation of bispecific radiotracers designed to target prostate-specific membrane antigen (PSMA) and fibroblast activation protein (FAP).
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Doctor shows patient anatomy image of prostate on computer.
Diagnostics

Heterodimeric radiotracer [68Ga]Ga-BQ7812 shows efficacy in models of prostate cancer

Oct. 18, 2022
Researchers from Uppsala University have...
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Gastric cancer
Cancer

KL-6, a novel benzochalcone derivative with promising efficacy in gastric cancer models

Oct. 14, 2022
Chinese researchers have detailed the discovery of a novel benzochalcone derivative being developed for the treatment of gastric cancer.
Read More
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