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BioWorld - Thursday, April 16, 2026
Home » Topics » Science » New compound

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Neurology/Psychiatric

Novel mPGES-1 inhibitor demonstrates neuroprotective effects in models of PD

Oct. 21, 2022
mPGES-1 is overexpressed in the dopaminergic neurons of the substantia nigra pars compacta of post-mortem brain tissue from patients with Parkinson’s disease (PD) as well as in 6-hydroxydopamine (6-OHDA)-injected PD mice.
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PET imaging
Diagnostics

Development of heterobivalent radiotracer targeting PSMA and GRPR

Oct. 21, 2022
Researchers have detailed the development and preclinical characterization of a novel heterobivalent radiotracer targeting prostate-specific membrane antigen (PSMA) and the gastrin-releasing peptide receptor (GRPR).
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HIV drugs
HIV/AIDS

ZLM-66, a promising new orally active biphenyl-containing doravirine analogue

Oct. 19, 2022
Researchers have discovered biphenyl-substituted pyridine derivatives of doravirine to be developed as novel HIV therapeutics.
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Prostate cancer cells
Diagnostics

Researchers develop bispecific PSMA/FAP radiotracers for prostate cancer imaging

Oct. 19, 2022
At the recent European Association of Nuclear Medicine meeting in Barcelona, researchers from the British Columbia Cancer Research Institute and the University of British Columbia reported the development and preclinical evaluation of bispecific radiotracers designed to target prostate-specific membrane antigen (PSMA) and fibroblast activation protein (FAP).
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Doctor shows patient anatomy image of prostate on computer.
Diagnostics

Heterodimeric radiotracer [68Ga]Ga-BQ7812 shows efficacy in models of prostate cancer

Oct. 18, 2022
Researchers from Uppsala University have...
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Gastric cancer
Cancer

KL-6, a novel benzochalcone derivative with promising efficacy in gastric cancer models

Oct. 14, 2022
Chinese researchers have detailed the discovery of a novel benzochalcone derivative being developed for the treatment of gastric cancer.
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Lung illustration
Respiratory

LAS-200813 shows strong antioxidant and antiapoptotic activity

Oct. 7, 2022
Researchers from Almirall SA and affiliated organizations reported the discovery and preclinical characterization of LAS-200813, a novel peptide inhibitor of the Keap1-Nrf2 protein-protein interaction.
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Neural network
Neurology/Psychiatric

AC-0027838 shows analgesic and anti-inflammatory activity in preclinical model

Sep. 27, 2022
Researchers from Alzecure Pharma AB have presented preclinical data on a novel TrkA negative allosteric modulator (NAM), AC-0027838, for...
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Electron micrograph of red blood cell infected with Plasmodium falciparum surrounded by knobless uninfected blood cells.
Infection

New classes of Plasmodium falciparum IspD could yield effective nanomolar antimalarials

Sep. 23, 2022
The 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, a metabolic pathway for the...
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Colorized scanning electron micrograph of Ebola virus.
Infection

Discovery of novel antiviral agents for the treatment of Ebola virus infection

Sep. 22, 2022
Researchers from Consejo Superior de Investigaciones Cientificas (CSIC) and affiliated organizations presented the discovery of a novel series of compounds acting as Ebola virus (EBOV) entry inhibitors.
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