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Home » Topics » Disease categories and therapies » Aging

Aging
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Hourglass, sunset, silhouettes
Genetic/congenital

Rockfish lifespan diversity gives insights into human aging GWAS

Jan. 16, 2023
By Anette Breindl
“Short-lived organisms represent a fundamentally different evolutionary strategy, and the idiosyncrasies influencing their aging may not apply to longer-lived models, including humans,” researchers from Harvard Medical School wrote in the Jan. 11, 2023, issue of Science Advances.


In their paper, the authors reported insights into the genomics of longevity that took advantage of an unusual animal model: rockfish.
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Comparison of senescent cells in regenerating muscle.
Musculoskeletal

Senescent cells are toxic to their neighbors, prevent muscle regeneration

Dec. 22, 2022
By Mar de Miguel
The first in vivo cell atlas of senescent tissue in skeletal muscle has identified the damaging properties of these cells and explained why they block muscle regeneration. According to a study at Pompeu Fabra University led by scientists from Altos Labs Inc., cell damage caused the senescence of the cells, which secreted toxic substances into the surrounding microenvironment, causing fibrosis and preventing tissue regeneration.
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Lab cultures of senescent human lung cells.
Immune

Low-dose checkpoint blockers have potential to slow aging processes

Nov. 10, 2022
By Tamra Sami
Low-dose administration of anti-PD-1 monoclonal antibodies could potentially reverse conditions associated with aging such as the accumulation of senescent cells and inflammation, according to a new study conducted at the Institute of Medical Science at the University of Tokyo.
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A young C. elegans adult
Genetic/Congenital

Proteostasis disruption links menopause to aging in C. elegans

Oct. 25, 2022
By Anette Breindl

Disrupted meiosis, the cell division process that leads to the production of reproductive cells in sexually reproducing organisms, led to a decline in overall health by triggering an accelerating aging signature in the roundworm Caenorhabditis elegans.

The work is “the first direct evidence that manipulating the health of reproductive cells leads to premature aging and a decline in healthspan,” senior author Arjumand Ghazi, an associate professor of pediatrics, developmental biology, and cell biology and physiology at the University of Pittsburgh and the University of Pittsburgh Medical Center (UPMC) Children’s Hospital, said in a press release.
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Two mouse fibroblasts image captured using structured illumination microscopy.
Biomarkers

‘Quite dynamic’ senescent cells can participate in tissue repair

Oct. 14, 2022
By Mar de Miguel
Fibroblasts expressing the tumor suppressor p16INK4a (a marker of senescence) stimulated lung stem cells from young mice to repair damaged tissue, according to a study from the University of California, San Francisco (UCSF). The finding calls into question therapies that eliminate these senescent cells without considering their beneficial role in tissue homeostasis.
Read More
Worms in a petri dish.
Biomarkers

Aging biomarkers may not generalize to lifespan

Oct. 7, 2022
By Anette Breindl
By independently manipulating the lifespan of worms and one of its purported biomarkers, namely, the cessation of vigorous movement (CVM), investigators at the Center for Genomic Regulation (CRG) in Barcelona have demonstrated that the two are driven by partly independent processes.
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Human aging illustration
Genetic/Congenital

Genetic influences on longevity depend on sex and age

Oct. 6, 2022
By Mar de Miguel
Researchers have gained new insights into both genetic and nongenetic factors affecting life span, and how they differ between males and females. Several genes were correlated with longevity, according to a study by the École Polytechnique Fédérale de Lausanne (EPFL). However, some did not affect life span until males reached a certain age. Early access to nutrients during growth also affected longevity, as they saw in their study of more than 3,000 mice and verified with human data. “This study is one of the biggest studies on mass longevity. We were looking for genetic determinants of longevity but there are non-genetic determinants affecting longevity,” the first author Maroun Bou Sleiman, researcher at EPFL, told Bioworld.
Read More

New regulatory path a must in quest for ‘fountain of youth’

Sep. 15, 2022
By Mari Serebrov
With the science on aging advancing, it’s time for the U.S. to modernize its regulatory approval path for new longevity treatments, members of a House Science, Space and Technology subcommittee were told Sept. 15.
Read More
Lysosome clusters in a mouse model of Alzheimer's disease.
Neurology/Psychiatric

Newly identified lysosomal repair pathway could prevent neurodegeneration

Sep. 14, 2022
By W. Todd Penberthy
Age-related diseases have been explained as due in part to the excessive generation and accumulation of waste products like the various insoluble protein aggregates observed in nondividing neurons of Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and Huntington’s disease.
Read More
Mitochondria illustration
Genetic/congenital

Pretzel Therapeutics launches with focus on mitochondrial biology

Sep. 13, 2022
Pretzel Therapeutics Inc. has launched with a $72.5 million series A financing to pioneer novel therapies to modulate mitochondrial function to treat rare genetic diseases and common diseases of aging.
Read More
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