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BioWorld - Tuesday, March 24, 2026
Breaking News: Trump administration impacts continue to roil the life sciences sectorBreaking News: Trump administration impacts continue to roil the life sciences sector
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In the clinic for Feb. 11, 2026

Feb. 11, 2026
Clinical updates for biopharma and med tech, including data readouts and publications: Accurkardia, Argá, Cardiol, Evommune, Hengrui, Merrylife, Nektar, Orsobio, Phio, Wat Medical.
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Appointments and advancements for Feb. 11, 2026

Feb. 11, 2026
New hires and promotions in the biopharma and med-tech industries, including: 4basebio, Boost, Imagenebio, Kdventures, Milestone, Okyo, Renovorx, Santa Ana, Spectral AI, Trisalus.
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Takeda’s oral narcolepsy drug steps closer to FDA approval

Feb. 11, 2026
By Marian (YoonJee) Chu
No Comments

The U.S. FDA accepted, with priority review, Takeda Pharmaceutical Co. Ltd.’s NDA submission for oveporexton (TAK-681), bringing the oral orexin receptor 2 agonist closer to clearance in narcolepsy type 1.


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3D dollar sign

Ascletis raises $107M to advance oral GLP-1 to phase III trials

Feb. 11, 2026
By Tamra Sami
No Comments
Ascletis Pharma Inc. raised HK$843.53 million (US107.93 million) in a placement on the Hong Kong Stock Exchange to advance its lead program, ASC-30, a small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist that can be dosed once monthly subcutaneously and once daily orally for treating obesity.
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Boston Scientific Farapulse PFS system

Boston Sci’s Farapulse better than thermal ablation at 4 years

Feb. 11, 2026
By Shani Alexander
No Comments
Boston Scientific Corp. recently reported new four-year data on its Farapulse pulsed field ablation platform, which demonstrated that patients with paroxysmal atrial fibrillation achieved better long-term success than those treated with thermal ablation. The data come as sales of the Farapulse system in the U.S. have begun to slow amid rising competition from other PFA technologies, particularly Medtronic plc’s Affera platform.
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Illustration of intestinal track

Microbiotica reports positive phase Ib data for live microbiome therapeutic

Feb. 11, 2026
By Nuala Moran
No Comments
Microbiome specialist Microbiotica Ltd. announced positive data from a phase Ib study of MB-310, an orally administered live biotherapeutic product for treating ulcerative colitis, with 12 of 19 treated patients achieving clinical remission, compared to three of 10 patients in the placebo arm.
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Upstream’s verekitug boat floats in asthma phase II

Feb. 11, 2026
By Randy Osborne
No Comments
Upstream Bio Inc.’s favorable top-line results from the phase II Valiant trial testing verekitug in adults with severe asthma were not enough to charm Wall Street, and shares of the firm (NASDAQ:UPB) closed Feb. 11 at $14.69, down $13.12, or 47%.
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Syringe in front of Moderna logo

Leave it to CBER: Prasad squad socks Moderna with flu RTF

Feb. 11, 2026
By Randy Osborne
No Comments
Moderna Inc. blamed a switcheroo by the U.S. FDA for the refusal-to-file (RTF) letter on the seasonal influenza vaccine mRNA-1010. Shares of the firm (NASDAQ:MRNA) closed Feb. 11 at $40.51, down $1.49, having traded as low as $36.66 as investors learned of the RTF letter, which Moderna said is “inconsistent with feedback” the company was given by regulators during pre-phase III as well as pre-BLA-submission talks.
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Illustration of human anatomy showing lymphatic system
Endocrine/metabolic

Targeting cholesterol deposition could treat lymphedema

Feb. 11, 2026
By Mar de Miguel
No Comments
The malfunction of lymphatic drainage that occurs in lymphedema leads to excessive cholesterol accumulation in the affected skin and lymphatic vessels, causing inflammation and fibrosis. However, surgery and the chemical reduction of accumulated cholesterol with cyclodextrin reduce inflammation and regenerate lymphatic vessels. Cholesterol is a potential therapeutic target for treating lymphedema, according to this study published on Feb. 11, 2026, in Nature by Veronique Angeli and her colleagues.
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Moderna dips on flu vaccine RTF letter

Feb. 11, 2026
No Comments
A preview of the next edition of BioWorld, Feb. 11, 2026
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