Aging is a major risk factor in most diseases. But much remains to be learned about how aging itself and age-associated diseases are coupled at the molecular level. Researchers from the Salk Institute for Biological Studies have identified a molecular link between aging and dementia through studies of the experimental compound J-147.
Immunological memory was once considered the sole provenance of the adaptive immune system's T and B cells, while the adaptive immune system "was thought to respond in the same naïve way every time," Niels Riksen told BioWorld.
Staphylococcus aureus’ role as a human pathogen may present a headache for gene editing. Looking at blood samples from human donors, researchers found that the majority of samples had pre-existing antibodies to the Cas9 from both S. aureus and Streptococcus pyogenes.
Treating mice with tungsten salt could reduce the numbers of Enterobacteriaceae specifically under the anaerobic conditions that are typical of inflammation, and reduced the symptoms of mice with colitis.
While the best thing to do with cancer cells is to kill them, the next best thing is to prevent them from growing. Chemotherapies often arrest their growth, forcing tumor cells into senescence.
Scientists have identified antibodies that stimulated bone marrow cells to differentiate into microglia-like cells and migrate to the brain, where they reduced the levels of amyloid plaque in mouse models of Alzheimer's disease.
