In the world of cancer genomics, mutational hotspots and cancer drivers are used somewhat interchangeably. "It was common knowledge... that if you see a site [mutated] in many cancers, that site is a driver," Gad Getz told BioWorld. But Getz, who is director of the Cancer Genome Computational Analysis Group at the Broad Institute of MIT and Harvard, and his team argue that the conventional wisdom is incorrect.
CAR T cells engineered to target fibroblast activating protein (FAP) could reverse cardiac fibrosis and restore cardiac function in mice, researchers have reported in the Sept. 12, 2019, issue of Nature.
By preventing ice formation while cooling human livers below freezing, researchers have managed to extend the viable lifespan of donated livers threefold.
Telomerase's reputation is that it has an important role in maintaining the ability of stem cells to divide through maintaining telomeres, the structures at the tips of chromosomes that shorten with each replication cycle.
Researchers at the University of California at San Diego have used a strategy of "rock-paper-scissors" to engineer more durable synthetic circuits into bacteria.
Three separate research teams have failed to replicate a 2016 primate study showing that treatment with a primate version of monoclonal antibody Entyvio (vedolizumab, Takeda Pharmaceutical Co. Ltd.), led to prolonged suppression of viremia in SHIV-infected monkeys.
Researchers at the Christian Albrechts University of Kiel and the MRC London Institute of Medical Science have developed a way to screen four-way interactions between genetically simple hosts, their microbiome, nutrients and drugs.
