BioWorld looks at translational medicine, including: Reversal of pumping direction is reversal of fortune for tumor cells; Cholesterol drug affects checkpoint blockade via MHC1; Heart development protein has role in adult immunity.
Keeping you up to date on recent developments in oncology, including: Blood test does well in distinguishing between malignant, benign growths; PARP inhibition can assist tumor cells; CDK 4/6 inhibitors affect transcriptional landscape.
Keeping you up to date on recent developments in diagnostics, including: Deep learning enables real-time prediction of acute kidney injury; Catching kidney injury early in children; Seeing where tau goes wrong.
Investigators at the National Institute of Allergy and Infectious Diseases have identified physiological factors that are not diseases in the narrow sense, but that nevertheless have large effects on microbiome composition.
One of the reasons that pancreatic cancer remains such a stubbornly dismal disease is that it is extremely desmoplastic. In other words, most of a pancreatic tumor is not made up of tumor cells, but of stroma. Stroma, in turn, is a double-edged sword for the tumor cells. Its connective tissue component impedes blood flow, which is part of what makes pancreatic cancer so drug-resistant. But the lack of blood also means a lack of oxygen and nutrients, so pancreatic tumors must find alternate ways to feed themselves. That’s where nerves come in. In the Nov. 2, 2020, online issue of Cell, researchers published new insights into how innervation feeds tumors, and how to stop them from doing so.
Keeping you up to date on recent developments in oncology, including: Microfluidic provides model for testing therapies on pancreatic ductal adenocarcinoma; Cutting off AML’s metabolic escape route; NGF: PDAC’s VEGF?; Revving up cisplatin by targeting Rev7.
Researchers at Stanford University have connected risk-associated single nucleotide polymorphisms for both Alzheimer's disease and Parkinson's disease to their possible causal genes via single-cell investigations into epigenomic states.
