Investigators have developed a new approach to classifying neurodegenerative disorders that used the overall patterns of protein aggregation, rather than specific proteins, to define six clusters of patients that crossed traditional diagnostic categories.
Investigators at Weill Cornell Medical College have demonstrated that mitochondrial DNA drives the abscopal antitumor response to radiation, which can be boosted by autophagy inhibition.
Keeping you up to date on recent developments in neurology, including: Brain computer improves function in paralyzed patient; Blood test could diagnose brain damage hours after birth; Power-saving, wireless neural implant developed; After injury, astrocytes can make interneurons.
BioWorld looks at translational medicine, including: PRC member affects blood formation during aging; Localized bile acid improves systemic blood glucose control; After injury, astrocytes can make interneurons; In AML, collapse prevents relapse; Starving out Chlamydia.
Keeping you up to date on recent developments in diagnostics, including: Facilitating analysis of scratch wound healing tests; Advanced imaging in children; Picturing molecular alterations.
BioWorld looks at translational medicine, including: Picturing molecular alterations; Fishing for druggable osteoporosis targets; First mouse-adapted strain of SARS-CoV-2; Transplanted iPSCs are best of both ApoE models; TXNIP inhibition nixes T2D; Degradation approach targets extracellular proteins; Tryptophan metabolites keep gut barrier strong; Honest placebos change brain potentials; Screening in serum yields active antibiotics.
Researchers from the Encyclopedia of DNA Elements (ENCODE) consortium reported data from the third phase of the project. Phase III data, which were published in more than a dozen papers in Nature and its sister journals on July 29, 2020, consisted of 6,000 experiments performed on around 1,300 samples.
By deleting the gene for uridine monophosphate synthetase (UMPS), an enzyme in the pathway for uridine synthesis, researchers have made cells, including embryonic stem cells and T cells, dependent on dietary uridine. The work, which was published in the July 13, 2020, online issue of Nature Biotechnology, adds a new potential way of controlling cell therapies.
CYBERSPACE – Data presented at the virtual 2020 Alzheimer's Association International Conference (AAIC) and reported in the July 28, 2020, online issue of the Journal of the American Medical Association (JAMA) demonstrated that blood levels of phosphorylated tau-217 (Ptau-217) did as well as cerebrospinal (CSF)- and PET-based biomarkers, and significantly better than other blood-based biomarkers, at discriminating individuals with Alzheimer’s disease (AD) from those with other neurodegenerative disorders.
