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BioWorld - Saturday, January 17, 2026
Home » Authors » Brian Orelli

Brian Orelli

Articles

ARTICLES

Retinal diseases: Firms see options beyond AMD incumbents

Aug. 24, 2015
By Brian Orelli
Without a doubt, wet age-related macular degeneration (AMD) has been a lucrative market for companies. Regeneron Pharmaceuticals Inc. announced $1.2 billion in U.S. sales of Eylea (aflibercept) in the first half of 2015, and Roche AG posted CHF769 million (US$804 million) in U.S. sales of Lucentis (ranibizumab).
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Increase in FDA approvals tied to fail fast and cheaply

Aug. 17, 2015
By Brian Orelli

Decades-old immunotherapy target CEA makes a comeback

Aug. 10, 2015
By Brian Orelli
Carcinoembryonic antigen (CEA) was one of the first oncoproteins discovered a half century ago. The protein is expressed in a subset of most epithelial cancers, including non-small-cell lung cancer, colorectal, pancreas, breast, gastric and medullary thyroid cancers. Globeimmune Inc. estimates that CEA is overexpressed in approximately 500,000 new cancer cases in the U.S. each year.
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Collaboration key to maximizing drug value

July 20, 2015
By Brian Orelli
Every drug company wants to get the best price for its drugs, but that's easier said than done, especially in the current environment with payers pushing back at high drug prices and pitting companies against each other to compete on price.
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Migraine drug target CGRP could get really profitable

July 13, 2015
By Brian Orelli
CGRP stands for calcitonin gene-related peptide but it might double for "could get really profitable" if drug companies targeting CGRP and its associated receptor are successful.
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VC investments hold steady in Q2, IPOs pick up steam

July 2, 2015
By Brian Orelli
It wasn't the perfect second quarter, but we'll take it. You'll recall, U.S. investments in private companies tracked by BioWorld in the first quarter of the year started off like gangbusters, more than doubling the funding in the year-ago quarter. IPOs, on the other hand, left something to be desired.
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Hemophilia market pushes toward prophylaxis, cures

June 29, 2015
By Brian Orelli
The hemophilia drug market is well established with multiple drugs designed to replace the underlying deficiency: factor VIII for hemophilia A and factor IX for hemophilia B.
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What’s got biotech worried? Just take a look at the 10-Ks

June 22, 2015
By Brian Orelli
Those forward-looking disclosures management reads at the beginning of presentations and the risk factors listed in their SEC filings are often viewed by investors as standard lawyer-speak to cover the company from potential lawsuits should something bad happen.
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New biotech ETFs look to slice up the biotech industry

June 8, 2015
By Brian Orelli
Investors wanting to buy into the high-growth biotech industry without purchasing shares of individual companies have had limited choices of exchange traded funds (ETFs).
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Personalized medicine on rise but challenges still exist

May 26, 2015
By Brian Orelli
"Personalized medicine," "precision medicine," "pharmacogenomics" or whatever you want to call it, it's pretty clear the industry is moving in the direction of having drugs to treat patients based on their genetic makeup.
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View All Articles by Brian Orelli

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