Severe malaria infections caused by malaria could disrupt hematopoietic processes in mouse models, resulting in faster turnover of hematopoietic stem cells (HSCs) and drastically affecting their function, researchers from Imperial College London and The Francis Crick Institute reported in the November 23, 2020, online issue of Nature Cell Biology.
By transplanting a plant-specific degradation pathway controlled by a phytohormone, auxin, into non-plant cells, researchers at the Japanese National Institutes of Genetics have developed a rapid protein degradation process – the auxin-inducible degron (AID) technology.
"RNA was long thought to be an 'undruggable' target for small molecules, because most cellular RNAs have extensive secondary structure, but only limited tertiary structure," Matthew Disney told BioWorld Science.
A multi-institutional team of researchers has discovered that acute lymphoblastic leukemia cells metabolically adapt to the cerebrospinal fluid-filled CNS microenvironment upon migration from the bone marrow with alterations in fatty acid synthetic pathways.
