Scientists from the UK Dementia Research Institute at the University of Cambridge have described how cytosolic antibody receptor TRIM21 contributes to in vivo protection during tau immunotherapy. Their work on TRIM21’s mechanism of action may help in moving a step closer toward enhanced second-generation antibodies for tauopathy treatments.

When undertaking a study on allergen-induced anaphylaxis in mice, researchers have found that not only the immune but also the nervous system may potentially play a part in the anaphylactic response. In their study published March 17, 2023, in Science Immunology, researchers from Duke University Medical Center reported that mice undergoing anaphylaxis displayed an “extended posture behavior” similar to the one that mice exhibit when exposed to high temperatures.