Biosimilar competition to Amgen Inc.’s denosumab (Prolia/Xgeva) is rising globally, with Mabwell (Shanghai) Bioscience Co. Ltd. gaining the latest China NMPA approval of Maiweijian (TK-006) on April 8. Mabwell’s wholly owned subsidiary, Jiangsu T-mab Biopharma Co. Ltd., gained NMPA clearance of Maiweijian (120 mg) as the first denosumab biosimilar for the indications of U.S.-licensed Xgeva for bone-related diseases.
The biosimilars revolution continues with the U.S. FDA’s approval of the first denosumab biosimilars: Wyost (denosumab-bbdz) and Jubbonti (denosumab-bbdz) from Sandoz Inc. for treating osteoporosis and to prevent bone problems in cancer. The approval puts up a strong challenge to Amgen Inc.’s Prolia, the first biologic for osteoporosis, and Xgeva, for bone cancer.
Sitryx Therapeutics Ltd. has identified nuclear factor erythroid 2-related factor 2 (NFE2-related factor 2; NFE2L2; NRF2) activators reported to be useful for the treatment of inflammatory disorders.
Nanchang Helioeast Technology Co. Ltd. has patented oxa-spirocyclic compounds acting as lysine-specific histone demethylase 1A (KDM1A; LSD1) inhibitors and reported to be useful for the treatment of acute myeloid leukemia.
By increasing the expression of the chloride transporter Kcc2 (K-Cl cotransporter 2), researchers at Duke University have reduced chronic pain in mouse models of nerve pain and bone cancer.
