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Home » Newsletters » BioWorld

BioWorld

Jan. 4, 2012

View Archived Issues

AVEO, Astellas Seek to Hang Tivozanib Hat on PFS Data

AVEO Pharmaceuticals Inc. and partner Astellas Pharma Inc. reported top-line data from the global, randomized Phase III TIVO-1 trial indicating that lead compound tivozanib demonstrated superiority over Nexavar (sorafenib, Onyx) in advanced renal cell carcinoma (RCC), meeting the primary endpoint of progression-free survival (PFS). Read More

Biotech Rings in 2012 With a Toast to 2011 VC Tallies

It was another heart attack-inducing year for biotech fans, with the market gyrations approaching the speed of light. Read More

New Insight into Hepatitis C Virus Cofactor MiRNA-122

Researchers from the University of North Carolina at Chapel Hill have gained new insights into why the hepatitis C virus needs the microRNA miR-122 as a partner in crime – and in doing so, have described a new general mechanism by which miRNAs can act on their targets to affect gene expression. Read More

Financings Roundup

• Bionovo Inc., of Emeryville, Calif., said it entered a $5 million securities purchase agreement with Socius CG II Ltd., a Bermuda-based subsidiary of Socius Capital Group LLC. Under the terms, the company has the right, at its discretion, to sell to Socius up to a total of $5 million of redeemable Series A preferred stock, payable in tranches, over a two-year period. Read More

U.S. Patent Disclosures

• Rexahn Pharmaceuticals Inc., of Rockville, Md., received U.S. Patent No. 8,034,829, titled "5, 6, or 7-Substituted-3-(hetero) arylisoquinolinamine derivatives and therapeutic use therof." It covers several new isoquinolinamine compounds and their pharmaceutical composition and method for producing an antitumor effect. Read More

Stock Movers

Read More

Other News To Note

• Astex Pharmaceuticals Inc., of Dublin, Calif., said the FDA's Oncologic Drugs Advisory Committee will discuss its supplemental new drug application for Dacogen (decitabine) for Injection at its Feb. 9, 2012, meeting. The proposed indication for the application is elderly acute myelogenous leukemia. Read More

Clinic Roundup

• Agile Therapeutics Inc., of Princeton, N.J., completed the final Phase III trial of AG200-15 and is on track to submit the new drug application (NDA) for the combination hormonal contraceptive patch to the FDA during the first quarter. The patch, in two Phase III trials enrolling more than 2,000 women, demonstrated its ability to deliver a low dose of ethinyl estradiol and a dose of levonorgestrel consistent with the efficacy and safety profiles of low-dose oral contraceptives. Read More

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