Biotech Co.*
(Country/
Symbol)

Agbiotech
Partner (Country/
Symbol)

Type/Product
Area

Disclosed
Funding
(M)

Terms/Details
(Date)


AviGenics
Inc.*

Demegen
Inc.
(DBOT)

Expanded research and development collaboration to develop disease-resistant poultry

ND

Demegen granted AviGenics an exclusive worldwide license for the antimicrobial peptide library and an additional license for Demegen's technologies for transgenic poultry creation; the collaboration will expand the incorporation of Demegen peptides into the poultry genome to impart resistance to Salmonella and Marek's disease, as well as to coccidiosis (1/26)

ComGenex (Hungary)*

Aventis Crop-
Science
(unit
of Aventis SA;
France;
NYSE:AVE)

Extended 1998 agreement to continue to provide access to in-house design and synthesis technologies and product management capabilities to Aventis

ND

Financial details not available (1/12)

CytRx Corp. (CYTR)

Ivy Animal
Health
Inc.*

Licensing agreement providing Ivy with an exclusive worldwide license to CRL-876

ND

The nonantibiotic feed additive is designed to enhance growth performance in monogastric food animals, including poultry and swine (2/20)

Genencor
International
Inc. (GCOR)

Cargill Inc.*

Agreement to supply biocatalysts for Cargill's wet corn-milling facilities

$70

Five-year exclusive supply agreement is valued at $70M (1/18)

GeneScan
Europe AG
(Germany)*

Clinical Micro Sensors (unit of Motorola Inc.; NYSE:MOT)

Technical collaboration to develop and deliver new DNA detection tools for genetically modified crops using Motorola's DNA detection system

ND

No further details were disclosed (1/30)

Genetic Technologies Ltd. (OTC
BB: GNTLF)

University of Melbourne (Australia)

Collaboration studying infectious diseases in livestock

ND

Collaboration will pursue a genomics approach to the diagnosis and treatment of infectious diseases in agricultural animals and common worms in domestic animals (1/5)

Genometrix
Inc.*

AniGenics
Inc.*

Agreement to genotype cattle for single nucleotide poly- morphisms associated with parentage confirmation, improved productivity and meat quality

ND

Financial terms were not disclosed (3/14)

GenomicFX
LP*

Incyte
Genomics
Inc.
(INCY)

Partnership calling for GenomicFX to use Incyte's gene databases and custom genomics services to develop advanced genetic information tools for use in improving meat quality, food safety and livestock production efficiency

ND

GenomicFX gains access to Incyte's LifeSeq Gold and Zooseq databases in addition to custom services from Incyte enabling the company to create database resources for cattle and swine (2/14)

Geron
Corp.
(GERN)

Clone Australia
Pty. Ltd.*

Licensing agreement for access to Geron's nuclear transfer technology to produce superior cattle and sheep for agricultural applications in Australia, New Zealand and China

ND

Geron will receive equity in Clone Australia, in addition to a share of revenues (1/10)

Geron
Corp.
(GERN)

Viragen Inc.
(AMEX:VRA)

Option agreement to license nuclear transfer technology

ND

Viragen has the option to license, on a nonexclusive worldwide basis, Geron's nuclear transfer patent portfolio for the field of avian nuclear transfer; Geron will receive cash and Viragen stock (6/7)

Geron
Corp.
(GERN)

ProLinia
Inc.*

Nonexclusive licensing agreement for nuclear transfer technology for agricultural applications

ND

ProLinia gains access to Geron's patents for use in swine worldwide and bovine everywhere except Australia and New Zealand (6/6)

Infigen
Inc.*

Immerge BioTherapeutics
Inc.
(joint venture between Novartis Pharma AG and BioTransplant Inc.; BTRN)

Partnership to use nuclear transfer technology to develop swine with more human organs

ND

Infigen will provide Immerge with exclusive access to its porcine NT technology; Immerge will provide the vectors for specific genes and cells from miniature swine (5/8)

Lynx Therapeutics
Inc.
(LYNX)

AniGenics
Inc.*

Agreement to use Lynx's Megasort and Megatype technologies to identify genes associated with commercially valuable traits in certain food animal species

ND

Lynx will receive payments for performing services, as well as royalties on sales of products and services from AniGenics; Lynx also retains rights to human health care applications of any discoveries and will pay royalties to AniGenics on any related products or services (5/8)

Meristem
Therapeutics
Inc.
(France)*

Goodwin
Biotechnology
Inc.*

Partnership agreement to expand the use of corn- and tobacco-based plant cultivation systems in North America

ND

The companies will set up a pilot manufacturing facility to cultivate genetically modified plants and the extraction and purification of recombinant proteins (4/4**)

Microscience Ltd. (UK)*

Merial (joint
venture between
Merck & Co.
Inc. and Aventis SA)

Collaboration to use functional genomics to develop two avian vaccines

ND

Deal includes up-front fees and milestone and royalty payments (6/5)

Myriad Genetics
Inc.
(MYGN)

Torrey Mesa
Research
Institute
(unit of
Syngenta)

Expanded agreement to include the use of Myriad's ProNet technology to elucidate the rice proteome

ND

Expanded agreement follows the collaboration's accomplishment of sequencing the entire rice genome (1/26)

Neogen
Corp.
(NEOG)

Monsanto Co. (NYSE:MON)

Nonexclusive agreement for access to Monsanto technology

ND

Neogen will develop tests for rapid detection of genetically enhanced grains; it also will market the tests (4/12)

Phytomedics
Ltd.*

Vilmorin Clause
& Cie
(France)*

Strategic collaboration combining Vilmorin's germplasm collections and Phytomedics' discovery and manufacturing platforms

ND

Companies will focus on developing and commercializing health-promoting crops and plant-derived therapeutic agents (6/14)

Sangamo
BioSciences
Inc.
(SGMO)

Renessen
LLC*

Agreement to apply Sangamo's gene regulation technology to enhance the value of certain crops for the animal feed and processing industries

ND

Sangamo will receive certain payments, research funding and royalties; Renessen gets a worldwide exclusive license (1/9)

Targeted
Growth
Inc.*

CropDesign
NV
(Belgium)*

Research collaboration
and technology cross-
licensing agreement

ND

TGI will give CropDesign several of its yield-enhancing genes for use in CropDesign's high-throughput Trait-Mill system and for use in commercial development in cereal crops (5/9)

Third Wave
Agbio Inc.*

ValiGen NV*

Agreement in which Third Wave will develop and supply custom-designed Invader assays to ValiGen

ND

ValiGen will use the platform to analyze genetic variations in several plant species (7/18)

ValiGen
NV*

Agricore (farmer-owned cooperative)

Agreement to develop and market specialty canola products

ND

ValiGen and Agricore will develop the products using ValiGen's Genoplasty system to change specific DNA sequences (5/17)

ViaLactia Biosciences Ltd. (New Zealand)*

Orion
Genomics

LLC*

Genomics alliance to develop improved varieties of forage plant species and hardier, higher-yielding crops

ND

Orion will use its GeneThresher technology to sequence and identify the complete gene set of a key forage grass species (6/1)

Vical Inc.
(VICL)

Merial (joint
venture between
Merck and Co.
Inc. and Aventis
SA)

Agreement to extend options under a 1995 deal for developing and commercializing vaccines for animal health applications using Vical's naked DNA technology

$1

Vical will receive $1M and Merial will receive a renewable one-year extension of its options against additional infectious disease targets in domesticated animals; Vical also will receive royalties on any vaccines sold (7/23)


Notes:

This chart contains information on new corporate agreements in agricultural biotechnology covering the time between 12/21/00 and 7/25/01.

Unless otherwise indicated, shares are traded on the Nasdaq exchange.

AMEX = American Stock Exchange; NYSE = New York Stock Exchange; OTC BB = Over the Counter Bulletin Board

ND = Not disclosed, reported and/or available

* Private companies are indicated with an asterisk.

** Denotes the date the item ran in BioWorld International.