| Company (Symbol) | Offer Date | Number Shares/ Units (M)* | Price Per Share/ Unit | Gross (M) | Net (M) | Shares Out (M) | Post Offering Market Cap (M)@ | Lead Under-writer** | Other Under-Writers |
| Gene Logic Inc. (GLGC) | 1/27 | 4.68S | $56.00 | $262 | $249 | 24.8 | $1,388.80 | INGB | CHQ RS, DRW |
| Vical Inc. (VICL) | 1/21 | 3.45 | $36.50 | $125.90 | $117.50 | 19.6 | $715.40 | GS | RS, SGC, FUS |
| Abgenix Inc. (ABGX) | 2/11 | 2.48S | $210 | $521.60 | $496.50 | 19.6 | $4,116 | RS | LB, ML, PGE |
| Celgene Corp. (CELG) | 2/10 | 2.48S | $101 | $250.90 | $235.30 | 20.7 | $2,090.70 | JPM PVHG | USBPJ |
| Genzyme Transgenics Corp. (GZTC) | 2/4 | 4.03S | $20 | $80.50 | $75.70 | 26.5 | $530 | WDR | CHQ |
| Maxim Pharmaceuticals Inc. (AMEX: MMP) | 2/22 | 3.21S | $55 | $176.30 | $164.90 | 19.7 | $1,083.50 | JPM | PVHG AS |
| Angiotech Pharmaceuticals Inc. (Canada; ANPI; TSE: ANP) | 3/22 | 1.75S | C$78.77 (US$53.50) | C$137.8 (US$93.6) | C$130..9 (US$88.9) | 17 | US$909.5 | DBAB ML | USBPJ LOM YS |
| Aradigm Corp. (ARDM) | 3/29 | 2.875S | $16 | $46 | $43.40 | 17.8 | $284.80 | CSFBC | SGC WDR IA |
| Biopure Corp. (BPUR) | 3/13 | 2.5S | $35 | $87.50 | $81.60 | 24.8 | $868 | JPM | SSB RWB AHH |
| Celera Genomics (NYSE:CRA) | 3/1 | 4.37S | $225 | $983.25 | $943.50 | 56.8 | $12,780 | MSDW GS | SGC INGB BSC |
| Centaur Pharmaceuticals Inc. | 3/30 | 1.9S | $11.50 | $21.90 | $20.70 | 17.5 | $201.25 | BJV | N/A |
| Diacrin Inc. (DCRN) | 3/22 | 3.45S | $11.50 | $39.70 | $36.80 | 17.9 | $205.85 | PW | NI |
| Emisphere Technologies Inc. (EMIS) | 3/14 | 2.75S | $72.75 | $200.10 | $188.10 | 17.3 | $1,258.60 | CHQ | DBAB WDR AHH |
| Entropin Inc. (OTC BB: ETOP) | 3/21 | 2U | $7.25 | $14.50 | $12.60 | 9.4 | $68.15 | NTB | WRI |
| Enzon Inc. (ENZN) | 3/21 | 2.3S | $44.50 | $102.40 | $95.70 | 40.3 | $1,793.40 | MSDW | CIBC SGC |
| Genentech Inc. (NYSE: DNA) | 3/23 | 17.3S | $163 | $2.8B | $2,772 | 260.3 | $42.4B | JPM | GS, ML WDR, LB RS |
| Maxygen (MAXY) | 3/20 | 1.5S | $97 | $145.50 | $137.40 | 32.3 | $3,133.10 | GS | RS, CSFBC, |
| Medarex Inc. (MEDX) | 3/3 | 2.4S | $172 | $412.70 | $388 | 35.1 | $6,037.20 | MSDW | CHQ DRW WDR |
| Nanogen Inc. (NGEN) | 3/16 | 1.5S | $55 | $82.50 | $76.70 | 20.5 | $1,127.50 | WDR | LB, PGE, DRW, FUS |
| Neose Technologies Inc. (NTEC) | 3/16 | 2.3S | $32 | $73.60 | $69 | 13.9 | $444.80 | CHQ | PVHG USBPJ WDR |
| Regeneron Pharmaceuticals Inc. (REGN) | 3/29 | 2.6S | $29.75 | $77.35 | $73 | 32.3 | $960.90 | ML | LB, JPM, RS |
| SuperGen Inc. (SUPG) | 3/16 | 1.465S | $45 | $65.90 | $61.30 | 29.1 | $1,309.50 | BAS | LB, PVHG, WDR |
| Tularik Inc. (TLRK) | 3/22 | 1.875S | $35.13 | $65.90 | $61.90 | 47.3 | $1,661.40 | LB | JPM, CHQ, TWP, WDR |
| Visible Genetics Inc. (VGIN) | 3/29 | 2S | 38 | $76 | $72.20 | 14.8 | $562.40 | RS | PW, WDR, RCP |
| Avigen Inc. (AVGN) | 4/13 | 1S | $26 | $26 | $23.80 | 16 | $416 | SSB | CIBC, INGB |
| Aviron (AVIR) | 4/4 | 2S | $22.50 | $45 | $41.80 | 20.2 | $454.50 | MSDW | BSC, USBPJ |
| Cambridge Antibody Technology plc (UK; LSE: CAT) | 4/3 | 4.86S | #18.50 (US$29.11) | #90 (US$141.6) | N/A | 33.7 | US$981 | DB | CAC |
| Corixa Corp. (CRXA) | 4/7 | 1.9S | $32 | $60.80 | $56.60 | 20.8 | $665.60 | WDR | LB, PVHG, PGE |
| Cubist Pharmaceuticals Inc. (CBST) | 4/6 | 2.875S | $33 | $94.90 | $89.20 | 23.5 | $775.50 | RS | PGE, CHQ, INGB, LFC |
| Ribozyme Pharmaceuticals Inc. (RZYM) | 4/6 | 3.15S | $18 | $56.70 | $52.70 | 15.2 | $273.60 | INGB | CHQ |
| Texas Biotechnology Corp. (AMEX:TXB) | 4/6 | 5S | $12.50 | $62.50 | $58.30 | 34.4 | $430 | PW | PVHG, FUS, SMH |
| Karo Bio AB (Sweden; Stockholm:KARO) | 5/18 | 0.6S | 336 SEK (US$36.69) | 201.6 SEK (US$22.0) | N/A | N/A | N/A | N/A | N/A |
| Lorus Therapeutics Inc. (Canada; OTC BB: LORFF) | 5/2 | 15.3S (US$2.03) | C$3 (US$31) | C$46 (US$29.0) | C$43 | N/A | N/A | HSBCS DDS | YS, TD, |
| Theratechnologies Inc. (Canada; TSE:TH) | 5/3 | 2.45S | C$8.60 (US$5.79) | C$21.04 (US$14.1) | C$19.8 (US$13.3) | 25.4 | US$147.1 | YS | BMO, NBF, DSI |
| SignalGene Inc. (Canada; TSE:SGI) | 6/13 | 12.5 | C$1.55 (US$1.05) | C$19.4 (US$13.2) | C$18.1 (US$12.3) | 102.3 | US$107.4 | BMO | NBF, YS |
| AVI BioPharma Inc. (AVII) | 7/27 | 3S | $7.25 | $21.75 | $19.80 | 21.4 | $155.15 | PIC | IBS, FCS |
| Zeltia (Spain) | 7/6 | 3S | EUR60.50 (US$57.64) | EUR181.5 (US$172.5) | N/A | N/A | N/A | HKSB CG | BSCH |
| AltaRex Corp. (Canada; TSE:AXO) | 8/9 | 10.6S | C$0.85 (US$ 0.57) | C$9 (US$6.1) | C$8.3 (US$5.6) | 72.5 | $41.30 | HSBCS | RCP, GG |
| The Immune Response Corp. (IMNR) | 8/8 | 2.76S | $6 | $16.60 | $14.90 | 29.8 | $178.80 | FSVK | GAC |
| Cell Therapeutics Inc. (CTIC) | 9/18 | 3.6S | $38 | $136.80 | $128.60 | 29.9 | $1,136.20 | CIBC USBPJ | N/A |
| NeoPharm Inc. (NEOL) | 9/26 | 3S | $35.50 | $106.50 | $99.80 | 14.1 | $500.55 | PVHG | USBPJ |
| Protein Design Labs Inc. (PDLI) | 9/26 | 3S | $118.40 | $355.30 | $337.10 | 42.8 | $5,067.50 | CSFBC CIBC | SGC |
| Albany Molecular Research Inc. (AMRI) | 10/6 | 3S | $42.25 | $126.75 | N/A | 32.8 | $1,385.80 | DBAB | CHQ, CIBC, PVHG, FAC |
| Dendreon Corp. (DNDN) | 10/27 | 2.5S | $15.63 | $39.10 | $36.40 | 24.2 | $378.10 | PVHG | SGC, PGE |
| Human Genome Sciences Inc. (HGSI) | 10/27 | 12.65S | $75 | $950 | N/A | 122.4 | $9,180 | CSFBC | GS, LB, CIBC, JPM, DRW |
| Insmed Inc. (INSM) | 10/27 | 5.5S | $11.88 | $65.30 | $60.80 | 32.7 | $388.30 | RS | BAS, PVHG |
| Millennium Pharmaceuticals Inc. (MLNM) | 10/6 | 11S | $64 | $704 | $677.20 | 209.7 | $13,420.80 | GS, MSDW | RS, CSFBC |
| Onyx Pharmaceuticals Inc. (ONXX) | 10/11 | 3.45S | $15 | $51.75 | $414 | 17.85 | $267.80 | USBPJ | CIBC |
| StressGen Biotechnologies Corp. (Canada; TSE:SSB) | 10/17 | 6.5S | C$7 (US$4.66) | C$45.5 (US$29.9) | C$42.2 (US$27.6) | 49.3 | $229.70 | BMO | CIBC, GMS |
| ArQule Inc. (ARQL) | 11/21 | 3.8S | $22.50 | $85.50 | $70.87 | 17.44 | $392.40 | WDR | CIBC GKMC LMWW |
| Avigen Inc. (AVGN) | 11/2 | 1.66S | $37.50 | $62.25 | $59 | 19.42 | $728.30 | ACS | N/A |
| Avigen Inc. (AVGN) | 11/15 | .69S | $45.06 | $31.30 | $29.90 | 19.42 | $875.10 | GFG | N/A |
| Cima Labs Inc. (CIMA) | 11/2 | 3.2S | $50 | $160 | $149.90 | 14.15 | $707.50 | DBAB | SGC, FC |
| Corvas International Inc. (CVAS) | 11/2 | 5.75S | $20 | $115 | $107.50 | 27 | $540 | CIBC USBPJ | PVHG |
| CuraGen Corp. (CRGN) | 11/16 | 4.8S | $41 | $196.80 | $186.50 | 42.1 | $1,726.10 | MSDW | DRW, BSC, PVHG, TWP |
| IDEC Pharmaceuticals Corp. (IDPH) | 11/16 | 2.6S | $181.81 | $472.70 | $449.50 | 47.8 | $8,690.50 | LB ML | SSB, BAS |
| Immunex Corp. (IMNX) | 11/10 | 80.5S | $39.75 | $3.2B | $2.71B | 558.5 | $22.2B | MSDW ML | CSFBC, LB, BAS, BSC, RS |
| ImmunoGen Inc. (IMGN) | 11/16 | 4S | $33 | $132 | $125.10 | 38.36 | $1,265.90 | SGC | RS, AHH |
| NPS Pharmaceuticals Inc. (NPSP) | 11/10 | 4.6S | $42 | $193.20 | $180.70 | 29.64 | $1,244.90 | CIBC | PVHG, RS |
| OSI Pharmaceuticals Inc. (OSIP) | 11/1 | 6.15S | $70 | $430.70 | $404 | 33.8 | $2,366 | RS, LB | PVHG, LFC, AHH |
| Bone Care International Inc. (BCII) | 12/12 | 2.3S | $16 | $36.80 | $33.90 | 13.8 | $220.80 | PVHG | USBPJ, RWB |
| ICOS Corp. (ICOS) | 12/14 | 5.175S | $37 | $191.48 | $181.40 | 51.7 | $1,912.90 | SGC | BAS, PVHG, RS, RMI |
| Neurocrine Biosciences Inc. (NBIX) | 12/6 | 3S | $30 | $90 | $84.10 | 25.1 | $753 | RS, SSB | N/A |
| North American Scientific Inc. (NASI) | 12/20 | 2.695S | $17.88 | $48.20 | $44.80 | 9.7 | $173.40 | CIBC | WDR, LS |
| Oxford GlycoSciences plc (UK; LSE:OGS; OGSI) | 12/8 | 13.37S | #12.75 (US$18.36) | #170.5 (US$254.5) | #137.5 (US$198) | N/A | N/A | LB | CSFBC, CC |
| January ¿ December 2000 FOLLOW-ON OFFERING TOTAL: $15,876.08M | |||||||||
| Notes: * Number of shares (or units) sold in the offering includes those sold to satisfy overallotment options, in full or in part, when disclosed. Likewise, gross proceeds include revenues for the sale of shares (or units) to satisfy overallotment options, in full or in part, where applicable. ** See Underwriters’ Key below. @ Market capitalization calculated is based on the offering price. All stocks listed on Nasdaq exchange unless otherwise noted. AMEX = American Stock Exchange; LSE = London Stock Exchange; NYSE = New York Stock Exchange; OTCBB = Over The Counter Bulletin Board; TSE = Toronto Stock Exchange. N/A = Not disclosed, reported and/or available Foreign currency is converted to U.S. dollars based on the exchange rate at the time of the offering. | |||||||||
| Underwriters’ Key: AGES (A.G. Edwards & Sons Inc.) | KBC (KBC Securities) KTM (KTM Capital Pty. Ltd.) LB (Lehman Brothers) LFC (Lazard Freres & Co. LLC) LMWW (Legg Mason Wood Walker) LOM (Loewen Ondaatje McCutcheon Ltd.) LS (Leerink, Swann & Co. Inc.) ML (Merrill Lynch & Co.) MSDW (Morgan Stanley, Dean Witter & Co.) PGE (Pacific Growth Equities Inc.) PVHG (Prudential Vector Healthcare Group) PW (PaineWebber Inc.) PZC (Punk Ziegel & Co.) RCP (Roth Capital Partners) RMI (Ragen Mackenzie Inc.) RS (Robertson Stephens Inc.) RWB (Robert W. Baird & Co.) SGC (SG Cowen Securities Corp.) SI (Stephens Inc.) SK (Stadtsparkasse Koln) SOJC (Sal. Oppenheim Jr. & Cie) SSB (Salomon Smith Barney Inc.) TACG (Tucker Anthony Cleary Gull) TKC (Thomas Kernaghan & Co.) TWP (Thomas Weisel Partners LLC) USBPJ (US Bancorp Piper Jaffray) WB (William Blair & Co.) WDR (Warburg Dillon Read LLC/UBS Warburg) WPL (WestLB Panmure Ltd.) WSV (Wit SoundView) | ||||||||
