BioWorld Quarterly Stock Report For Public Biotechnology Companies
| Company | Symbol | 12/31* | 3/31 | 6/30 | 9/30 | %YTD |
| Aastrom Biosci | ASTM | 4.375 | 4.500 | 3.750 | 2.125 | -51 |
| Abgenix (1) | ABGX | 8.000 | — | — | 7.125 | -11 |
| Adv Magnetics | AVM | 8.750 | 13.062 | 11.312 | 7.500 | -14 |
| Adv Poly Sys | APOS | 6.625 | 8.625 | 7.000 | 5.437 | -18 |
| Adv Tissue Sci | ATIS | 12.375 | 9.343 | 4.437 | 3.031 | -76 |
| Affymetrix | AFFX | 31.125 | 34.812 | 24.062 | 25.750 | -17 |
| Agouron | AGPH | 29.375 | 37.875 | 30.312 | 34.437 | 17 |
| Agritope | AGTO | 7.000 | 4.500 | 4.000 | 1.375 | -80 |
| Alexion Pharma | ALXN | 12.500 | 12.375 | 10.000 | 9.250 | -26 |
| Alkermes | ALKS | 19.875 | 24.875 | 17.875 | 14.562 | -27 |
| Allelix | AXB* | 11.500 | 9.000 | 8.000 | 3.350 | -71 |
| Alliance | ALLP | 7.250 | 7.562 | 4.187 | 3.062 | -58 |
| Alpha Beta | ABTI | 2.593 | 2.125 | 2.437 | 1.343 | -48 |
| AltaRex | AXO* | 3.000 | 2.260 | 1.050 | 0.780 | -74 |
| Alteon | ALTN | 7.312 | 5.062 | 3.500 | 3.000 | -59 |
| Alza | AZA | 31.812 | 44.812 | 43.250 | 43.375 | 36 |
| Am Bio Sci | MABXA | 1.906 | 1.750 | 1.156 | 0.406 | -79 |
| Amarillo Biosci | AMAR | 5.500 | 3.250 | 2.750 | 2.000 | -64 |
| AMBI Inc. | AMBI | 1.937 | 2.187 | 1.406 | 0.781 | -60 |
| Amgen | AMGN | 54.125 | 60.875 | 65.375 | 75.562 | 40 |
| Amylin | AMLN | 5.437 | 2.750 | 3.781 | 3.187 | -41 |
| Anergen | ANRG | 2.125 | 1.062 | 1.937 | 1.187 | -44 |
| Anesta | NSTA | 16.375 | 18.625 | 14.437 | 18.625 | 14 |
| Angiotech Pharma | ANP* | 10.000 | 16.500 | 14.750 | 9.000 | -10 |
| Aphton | APHT | 10.125 | 12.687 | 16.625 | 11.750 | 16 |
| Aquila Biopharma | AQLA | 4.187 | 7.125 | 4.187 | 2.875 | -31 |
| Aradigm | ARDM | 8.500 | 12.625 | 13.562 | 10.000 | 18 |
| Ariad Pharm | ARIA | 4.250 | 4.625 | 3.562 | 2.750 | -35 |
| Aronex Pharma | ARNX | 4.250 | 3.562 | 3.937 | 2.625 | -38 |
| ArQule | ARQL | 22.937 | 22.250 | 12.937 | 7.500 | -67 |
| Atlantic Pharma | ATLC | 6.750 | 6.500 | 3.812 | 1.750 | -74 |
| Atrix Labs | ATRX | 14.750 | 19.000 | 13.375 | 12.625 | -14 |
| Aurora Bioscience | ABSC | 13.125 | 11.500 | 5.875 | 6.000 | -54 |
| AutoImmune | AIMM | 3.312 | 2.312 | 2.562 | 1.875 | -43 |
| Avant Immuno (2) | AVAN | 2.437 | 2.938 | 2.500 | 1.375 | -44 |
| Avax Technologies | AVXT | 3.687 | 4.250 | 2.437 | 1.750 | -53 |
| AVI BioPharma | AVII | 6.812 | 7.125 | 6.250 | 3.375 | -50 |
| Avigen | AVGN | 2.250 | 2.437 | 3.500 | 2.750 | 22 |
| Aviron | AVIR | 27.125 | 23.125 | 31.187 | 15.437 | -43 |
| Axogen | AXG/U | 39.750 | 57.000 | 63.000 | 69.250 | 74 |
| Axys Pharma | AXPH | 8.375 | 8.750 | 7.125 | 4.375 | -48 |
| Bio-Tech Gen | BTGC | 10.750 | 8.500 | 7.093 | 6.625 | -38 |
| Biochem Pharma | BCHE | 20.875 | 24.187 | 26.500 | 18.375 | -12 |
| BioCryst | BCRX | 7.000 | 7.500 | 7.812 | 7.000 | 0 |
| Biogen | BGEN | 36.375 | 48.187 | 49.000 | 65.812 | 81 |
| Bioject | BJCT | 1.281 | 1.500 | 1.812 | 1.562 | 22 |
| Biomatrix (3) | BXM | 30.000 | 29.875 | 41.000 | 39.000 | 30 |
| Biomira | BIOMF | 2.125 | 2.500 | 2.250 | 1.531 | -28 |
| Biomune Sys | BIME | 0.718 | 0.937 | 0.937 | 0.406 | -43 |
| Biora AB | BIORY | 20.750 | 25.000 | 26.500 | 20.875 | 1 |
| Bioreliance | BREL | 23.000 | 16.500 | 15.062 | 10.500 | -54 |
| Biotime | BTIM | 19.000 | 14.250 | 6.250 | 9.000 | -53 |
| BioTransplant | BTRN | 5.750 | 4.250 | 3.500 | 1.500 | -74 |
| Boston Life | BLSI | 2.281 | 2.125 | 3.125 | 2.968 | 30 |
| British Biotech | BBIOY | 16.625 | 12.250 | 6.375 | 5.750 | -65 |
| Cadus Pharma | KDUS | 6.375 | 8.312 | 7.750 | 2.812 | -56 |
| Calypte Biomed | CALY | 3.875 | 5.187 | 4.031 | 1.750 | -55 |
| Cambridge Neuro | CNSI | 1.968 | 2.312 | 0.593 | 0.531 | -73 |
| Cantab Pharm | CNTBY | 11.750 | 13.573 | 12.125 | 10.125 | -14 |
| Carrington | CARN | 4.312 | 4.437 | 4.812 | 3.250 | -25 |
| Cel-Sci | HIV | 6.625 | 4.625 | 4.937 | 2.625 | -60 |
| Celgene | CELG | 8.437 | 10.875 | 10.625 | 9.812 | 16 |
| Cell Genesys | CEGE | 8.500 | 6.625 | 8.562 | 3.187 | -63 |
| Cell Therapeutics | CTIC | 17.000 | 4.125 | 2.687 | 2.125 | -88 |
| Cellegy Pharma | CLGY | 8.375 | 7.125 | 5.562 | 4.125 | -51 |
| CellPro | CPRO | 2.312 | 3.625 | 3.062 | 0.062 | -97 |
| Celtrix | CTRX | 1.812 | 2.812 | 2.062 | 1.000 | -45 |
| Centocor | CNTO | 33.250 | 44.625 | 36.250 | 39.625 | 19 |
| Cephalon | CEPH | 11.375 | 14.000 | 7.875 | 7.312 | -36 |
| ChemTrak (4) | CMTR | 3.750 | 0.718 | 0.187 | 0.125 | -97 |
| Chiron | CHIR | 17.000 | 20.937 | 15.687 | 19.875 | 17 |
| Cholestech | CTEC | 12.500 | 15.000 | 6.750 | 4.687 | -63 |
| Chrysalis Intl | CRLS | 2.156 | 3.000 | 1.375 | 0.812 | -62 |
| CIMA Labs | CIMA | 4.250 | 4.968 | 3.343 | 2.875 | -32 |
| CliniChem Dev (5) | CCHE | 8.375 | — | 5.750 | 4.687 | -44 |
| ClinTrials | CCRO | 7.875 | 7.125 | 4.875 | 4.750 | -40 |
| CoCensys | COCN | 3.437 | 3.062 | 2.500 | 2.031 | -41 |
| Collab. Clin. Res | CCLR | 5.062 | 4.250 | 4.125 | 2.812 | -44 |
| CollaGenex | CGPI | 12.500 | 9.343 | 8.625 | 13.250 | 6 |
| Collateral Thera (6) | CLTX | 7.250 | — | — | 6.000 | -17 |
| Columbia Labs | COB | 16.250 | 13.812 | 5.750 | 3.750 | -77 |
| CombiChem | CCHM | 8.000 | — | 6.937 | 4.000 | -50 |
| Connetics Corp. | CNCT | 3.062 | 5.312 | 3.812 | 3.687 | 20 |
| Cor Thera | CORR | 22.500 | 12.375 | 13.875 | 7.750 | -66 |
| Corixa | CRXA | 8.937 | 7.375 | 6.875 | 6.125 | -31 |
| Cortecs Intl | DLVRY | 14.250 | 14.375 | 7.375 | 3.500 | -75 |
| Cortex | CORX | 1.500 | 1.750 | 1.875 | 1.312 | -13 |
| Corvas | CVAS | 3.875 | 5.000 | 4.125 | 2.062 | -47 |
| Coulter Pharma | CLTR | 20.250 | 27.375 | 30.375 | 24.875 | 23 |
| Creative Bio | CBMI | 7.375 | 8.250 | 4.812 | 3.000 | -59 |
| Crescendo | CNDO | 11.562 | 12.625 | 12.687 | 13.187 | 14 |
| Cubist Pharma | CBST | 5.812 | 4.500 | 4.750 | 2.437 | -58 |
| Curagen Corp. | CRGN | 11.500 | 11.562 | 6.250 | 6.000 | -48 |
| CV Therapeutics | CVTX | 9.375 | 9.500 | 8.625 | 5.750 | -39 |
| Cyanotech | CYAN | 2.781 | 3.437 | 3.125 | 1.687 | -39 |
| Cygnus | CYGN | 19.875 | 16.500 | 10.437 | 3.500 | -82 |
| Cypress Bio | CYPB | 1.437 | 2.625 | 2.968 | 2.765 | 92 |
| Cypros Pharma | CYP | 4.250 | 3.812 | 4.062 | 2.812 | -34 |
| Cytel | CYTL | 1.500 | 1.781 | 1.375 | 0.875 | -42 |
| Cytoclonal | CYPH | 6.875 | 10.250 | 7.000 | 6.250 | -9 |
| Cytogen | CYTO | 1.625 | 2.156 | 0.781 | 0.812 | -50 |
| CytoTherapeut | CTII | 4.000 | 3.375 | 1.250 | 0.937 | -77 |
| CytRx | CYTR | 2.937 | 3.375 | 2.125 | 0.906 | -69 |
| Dekalb | DKB | 39.250 | 66.875 | 94.625 | 92.000 | 134 |
| DepoMed | DPMD | 4.250 | 12.375 | 10.250 | 8.750 | 106 |
| DepoTech | DEPO | 3.562 | 6.000 | 1.562 | 1.062 | -70 |
| Diacrin | DCRN | 10.125 | 9.750 | 6.250 | 7.281 | -28 |
| Diagnostic Prod | DP | 27.750 | 27.875 | 28.812 | 26.687 | -4 |
| Dianon Systems | DIAN | 9.375 | 9.750 | 9.250 | 6.125 | -35 |
| Diatide | DITI | 9.125 | 10.750 | 8.750 | 6.875 | -25 |
| Digene | DIGE | 8.625 | 8.875 | 9.750 | 7.250 | -16 |
| Discovery Labs | DSCO | 4.000 | 4.750 | 4.250 | 2.375 | -41 |
| DNAP Holding | DNAP | 4.859 | 4.000 | 4.187 | 3.625 | -25 |
| Draxis Health | DRAXF | 3.062 | 2.906 | 2.562 | 1.812 | -41 |
| Dura Pharm | DURA | 45.875 | 24.625 | 22.375 | 10.937 | -76 |
| Dusa Pharma | DUSA | 11.500 | 15.500 | 6.812 | 3.562 | -69 |
| DynaGen | DYGN | 1.400 | 0.562 | 0.437 | 0.218 | -84 |
| Ecogen | EECN | 1.937 | 2.687 | 2.625 | 1.312 | -32 |
| Elan | ELN | 51.187 | 64.625 | 64.312 | 72.062 | 41 |
| Embrex | EMBX | 5.312 | 5.750 | 6.187 | 4.562 | -14 |
| Emisphere | EMIS | 18.625 | 17.875 | 12.062 | 7.875 | -58 |
| Endorex (7) | DOR | 5.500 | 6.187 | 4.250 | 2.375 | -57 |
| EntreMed | ENMD | 11.312 | 12.812 | 33.250 | 24.125 | 113 |
| Envirogen | ENVG | 1.500 | 1.250 | 1.250 | 0.500 | -67 |
| Enzo Biochem | ENZ | 14.625 | 15.750 | 13.375 | 7.000 | -52 |
| Enzon | ENZN | 5.500 | 6.875 | 6.375 | 6.625 | 20 |
| Epitope | EPTO | 5.000 | 6.875 | 6.500 | 3.750 | -25 |
| Epix Medical | EPIX | 13.000 | 13.187 | 10.250 | 9.562 | -26 |
| Ergo Science | ERGO | 15.250 | 15.062 | 3.562 | 3.250 | -79 |
| Ethical Hldgs | ETHCY | 3.125 | 3.000 | 0.375 | 0.156 | -95 |
| Flamel Tech | FLMLY | 1.812 | 5.125 | 5.000 | 2.875 | 59 |
| GalaGen | GGEN | 1.875 | 1.625 | 3.062 | 1.812 | -3 |
| GelTex | GELX | 26.500 | 27.000 | 18.625 | 21.125 | -20 |
| Gene Logic | GLGC | 8.000 | 7.625 | 7.000 | 3.937 | -51 |
| Genelabs | GNLB | 2.812 | 4.000 | 3.000 | 2.312 | -18 |
| GeneMedicine | GMED | 5.062 | 2.875 | 3.125 | 2.437 | -52 |
| Genentech | GNE | 60.625 | 70.437 | 67.875 | 71.875 | 19 |
| Genetronics | GEB* | 3.094 | 3.550 | 3.600 | 4.300 | 39 |
| Genome Thera | GENE | 6.312 | 8.625 | 4.500 | 2.125 | -66 |
| Genset | GENXY | 19.750 | 29.000 | 29.375 | 25.750 | 30 |
| Gensia Sicor | GNSA | 5.812 | 5.000 | 4.000 | 4.062 | -30 |
| Genta | GNTA | 0.781 | 0.968 | 1.343 | 0.937 | 20 |
| Genz Tiss Repair | GENZL | 6.875 | 8.625 | 6.562 | 3.000 | -56 |
| Genzyme | GENZ | 27.750 | 32.000 | 25.562 | 36.125 | 30 |
| Genzyme Trans | GZTC | 9.625 | 11.562 | 7.750 | 4.000 | -58 |
| Geron | GERN | 8.250 | 12.375 | 9.375 | 6.125 | -26 |
| Gilead Sciences | GILD | 38.250 | 36.000 | 32.062 | 21.625 | -43 |
| Gliatech | GLIA | 10.250 | 12.125 | 16.125 | 16.125 | 57 |
| Guilford Pharm | GLFD | 20.125 | 22.000 | 17.625 | 14.000 | -30 |
| Hemacare | HEMA | 0.468 | 0.687 | 0.531 | 0.343 | -27 |
| Hemosol | HML* | 2.188 | 1.797 | 2.980 | 2.500 | 14 |
| Human Genome | HGSI | 39.750 | 39.812 | 35.687 | 30.000 | -25 |
| Hycor Bio | HYBD | 1.562 | 1.750 | 2.000 | 1.750 | 12 |
| Hyseq | HYSQ | 9.625 | 12.500 | 10.812 | 5.437 | -44 |
| Icon plc (8) | ICLRY | 18.000 | — | 25.250 | 32.625 | 81 |
| Icos | ICOS | 18.312 | 15.250 | 19.125 | 17.750 | -3 |
| ID Biomed | IDB* | 3.400 | 5.150 | 6.050 | 4.000 | 18 |
| IDEC Pharm | IDPH | 34.375 | 44.250 | 23.562 | 23.750 | -31 |
| Idexx Labs | IDXX | 15.937 | 18.000 | 24.875 | 23.875 | 50 |
| Igen | IGEN | 13.250 | 42.375 | 40.875 | 28.250 | 113 |
| ILEX Oncology | ILXO | 7.375 | 10.125 | 9.875 | 8.687 | 18 |
| ImClone Sys | IMCL | 8.125 | 8.312 | 12.250 | 8.750 | 8 |
| Immucell | ICCC | 2.468 | 1.937 | 2.187 | 1.937 | -22 |
| Immucor | BLUD | 8.625 | 9.625 | 8.687 | 9.750 | 13 |
| ImmuLogic | IMUL | 1.875 | 1.656 | 1.625 | 1.406 | -25 |
| Immune Resp | IMNR | 11.125 | 9.812 | 15.000 | 11.500 | 3 |
| Immunex | IMNX | 54.000 | 67.375 | 66.250 | 55.375 | 3 |
| ImmunoGen | IMGN | 0.843 | 1.687 | 1.750 | 1.312 | 56 |
| Immunomed | IMMU | 3.625 | 5.062 | 4.437 | 3.500 | -3 |
| Incyte Pharm | INCY | 45.000 | 46.750 | 34.125 | 21.250 | -53 |
| Inhale Ther Sys | INHL | 26.000 | 27.125 | 24.750 | 28.000 | 8 |
| InKine Pharma | INKP | 1.375 | 1.343 | 1.281 | 0.937 | -32 |
| Innovir | INVR | 0.375 | 0.718 | 0.343 | 0.156 | -58 |
| InSite Vision | ISV | 3.250 | 3.375 | 3.375 | 1.937 | -40 |
| Integra LifeScien | IART | 8.875 | 8.875 | 7.000 | 4.687 | -47 |
| Intercardia | ITRC | 17.875 | 20.375 | 10.000 | 3.625 | -80 |
| Interferon Sci | IFSC | 8.687 | 7.125 | 1.156 | 0.625 | -93 |
| Interneuron | IPIC | 9.500 | 10.437 | 3.625 | 3.000 | -68 |
| Isis Pharm | ISIP | 12.312 | 15.250 | 13.687 | 11.375 | -8 |
| La Jolla Pharm | LJPC | 4.437 | 3.875 | 3.500 | 2.875 | -35 |
| LeukoSite | LKST | 10.937 | 9.250 | 7.375 | 7.500 | -31 |
| Lidak Pharm | LDAKA | 2.375 | 1.781 | 1.500 | 1.125 | -53 |
| Life Tech | LTEK | 33.250 | 38.500 | 31.375 | 33.375 | 0 |
| Lifecell | LIFC | 4.625 | 5.093 | 6.125 | 3.937 | -15 |
| Lifecore Bio | LCBM | 21.875 | 23.375 | 16.500 | 7.500 | -66 |
| Ligand | LGND | 12.875 | 15.937 | 12.875 | 9.125 | -29 |
| Liposome Co | LIPO | 4.625 | 5.562 | 5.406 | 5.687 | 23 |
| LJL Biosystems | LJLB | 7.000 | 7.062 | 4.875 | 2.500 | -64 |
| LXR Biotech | LXR | 2.375 | 3.812 | 1.937 | 1.375 | -42 |
| Lynx Therapeutics | LYNX | 16.250 | 10.000 | 9.375 | 8.125 | -50 |
| NOTES: | ||||||
| 1. Abgenix Inc. (NASDAQ:ABGX) completed its IPO 7/2/98. The stock was priced at $8.00 per share. | ||||||
| 2. T Cell Sciences Inc. (NASDAQ:TCEL) has merged with Virus Research Institute Inc. (NASDAQ:VRII) to form Avant Immunotherapeutics Inc. | ||||||
| (NASDAQ:AVAN), effective 8/24/98. | ||||||
| 3. Biomatrix Inc.'s stock, which had been trading on NASDAQ under the symbol BIOX, started trading instead on the New York Stock Exchange under the symbol BXM, effective 7/23/98. | ||||||
| 4. ChemTrak Inc. (NASDAQ:CMTR) reverse-split its stock 5 for 1, effective 8/3/98. The historical prices have been adjusted accordingly. | ||||||
| 5. CliniChem Development Inc. has been spun off from BioChem Pharma Inc. (NASDAQ:BCHE) by way of a special distribution of CliniChem shares to BioChem Pharma's shareholders. CliniChem's stock started trading on NASDAQ under the symbol CCHE on 6/18/98. | ||||||
| 6. Collateral Therapeutics Inc. (CLTX) completed its IPO 7/2/98. The stock was priced at $7.25 per share. | ||||||
| 7. Endorex Corp.'s stock, which had been trading on the OTC Bulletin Board under the symbol ENDR, starting trading instead on the American Stock Exchange under the symbol DOR, effective 8/6/98. | ||||||
| 8. Icon plc (NASDAQ:ICLRY) completed its IPO 5/14/98. The stock was priced at $18.00 per American Depository Share (ADS, where 1 ADS = 1 common share). | ||||||
| * The prices listed in the 12/31/97 column represent the 1997 closing prices or, for those stocks that started trading in 1998, the IPO prices. There are 309 stocks on this list; the average percent change year-to-date is -25.97%. | ||||||