BioWorld Quarterly Stock Report For Public Biotechnology Companies
Company Symbol 12/31/97* 3/31 %YTDAastrom Biosci ASTM 4.375 4.500 3
Adv Magnetics AVM 8.750 13.062 49
Adv Poly Sys APOS 6.625 8.625 30
Adv Tissue Sci ATIS 12.375 9.343 -25
Affymetrix AFFX 31.125 34.812 12
Agouron AGPH 29.375 37.875 29
Agritope AGTO 7.000 4.500 -36
Alexion Pharma ALXN 12.500 12.375 -1
Alkermes ALKS 19.875 24.875 25
Allelix AXB* 11.500 9.000 -22
Alliance ALLP 7.250 7.562 4
Alpha Beta ABTI 2.593 2.125 -18
AltaRex AXO* 3.000 2.260 -25
Alteon ALTN 7.312 5.062 -31
Alza AZA 31.812 44.812 41
Am Bio Sci MABXA 1.906 1.750 -8
Amarillo Biosci AMAR 5.500 3.250 -41
AMBI Inc. AMBI 1.937 2.187 13
Amgen AMGN 54.125 60.875 12
Amylin AMLN 5.437 2.750 -49
Anergen ANRG 2.125 1.062 -50
Anesta NSTA 16.375 18.625 14
Angiotech Pharma ANP* 10.000 16.500 65
Aphton APHT 10.125 12.687 25
Aquila Biopharma AQLA 4.187 7.125 70
Ariad Pharm ARIA 4.250 4.625 9
Aronex Pharma ARNX 4.250 3.562 -16
ArQule ARQL 22.937 22.250 -3
Atlantic Pharma ATLC 6.750 6.500 -4
Atrix Labs ATRX 14.750 19.000 29
Aurora Bioscience ABSC 13.125 11.500 -12
AutoImmune AIMM 3.312 2.312 -30
Avax Technologies AVXT 3.687 4.250 15
AVI BioPharma (1) AVII 6.812 7.125 5
Avigen AVGN 2.250 2.437 8
Aviron AVIR 27.125 23.125 -15
Axogen AXG/U 39.750 57.000 43
Axys Pharma (2) AXPH 8.375 8.750 4
Bio-Tech Gen BTGC 10.750 8.500 -21
Biochem Pharma BCHE 20.875 24.187 16
Biocircuits (3) BIOC 2.188 1.468 -33
BioCryst BCRX 7.000 7.500 7
Biogen BGEN 36.375 48.187 32
Bioject BJCT 1.281 1.500 17
Biomatrix BIOX 30.000 29.875 0
Biomira BIOMF 2.125 2.500 18
Biomune Sys BIME 0.718 0.937 31
Biora AB BIORY 20.750 25.000 20
Bioreliance BREL 23.000 16.500 -28
Biotime BTIM 19.000 14.250 -25
BioTransplant BTRN 5.750 4.250 -26
Boston Life BLSI 2.281 2.125 -7
British Biotech BBIOY 16.625 12.250 -26
Cadus Pharma KDUS 6.375 8.312 30
Calypte Biomed CALY 3.875 5.187 34
Cambridge Neuro CNSI 1.968 2.312 17
Cantab Pharm CNTBY 9.625 11.125 16
Carrington CARN 4.312 4.437 3
Cel-Sci HIV 6.625 4.625 -30
Celgene CELG 8.437 10.875 29
Cell Genesys CEGE 8.500 6.625 -22
Cell Therapeutics CTIC 17.000 4.125 -76
Cellegy Pharma CLGY 8.375 7.125 -15
CellPro CPRO 2.312 3.625 57
Celtrix CTRX 1.812 2.812 55
Centocor CNTO 33.250 44.625 34
Cephalon CEPH 11.375 14.000 23
ChemTrak CMTR 0.750 0.718 -4
Chiron CHIR 17.000 20.937 23
Cholestech CTEC 12.500 15.000 20
Chrysalis Intl CRLS 2.156 3.000 39
CIMA Labs CIMA 4.250 4.968 17
ClinTrials CCRO 7.875 7.125 -10
CoCensys COCN 3.437 3.062 -11
Collab. Clin. Res CCLR 5.062 4.250 -16
CollaGenex CGPI 12.500 9.343 -25
Columbia Labs COB 16.250 13.812 -15
Connetics Corp. CNCT 3.062 5.312 73
Cor Thera CORR 22.500 12.375 -45
Corixa CRXA 8.937 7.375 -17
Cortech CRTQ 0.593 0.500 -16
Cortecs Intl DLVRY 14.250 14.375 1
Cortex CORX 1.500 1.750 17
Corvas CVAS 3.875 5.000 29
Coulter Pharma CLTR 20.250 27.375 35
Creative Bio CBMI 7.375 8.250 12
Crescendo Pharma CNDO 11.562 12.625 9
Cubist Pharma CBST 5.812 4.500 -23
Curagen Corp. (4) CRGN 11.500 11.562 1
CV Therapeutics CVTX 9.375 9.500 1
Cyanotech CYAN 2.781 3.437 24
Cygnus CYGN 19.875 16.500 -17
Cypress Bio CYPB 1.437 2.625 83
Cypros Pharma (5) CYP 4.250 3.812 -10
Cytel CYTL 1.500 1.781 19
Cytoclonal Pharma CYPH 6.875 10.250 49
Cytogen CYTO 1.625 2.156 33
CytoTherapeut CTII 4.000 3.375 -16
CytRx CYTR 2.937 3.375 15
Dekalb DKB 39.250 66.875 70
DepoMed DPMD 4.250 12.375 191
DepoTech DEPO 3.562 6.000 68
Diacrin DCRN 10.125 9.750 -4
Diagnostic Prod DP 27.750 27.875 0
Dianon Systems DIAN 9.375 9.750 4
Diatide DITI 9.125 10.750 18
Digene DIGE 8.625 8.875 3
Discovery Labs DSCO 4.000 4.750 19
DNAP Holding DNAP 4.859 4.000 -18
Draxis Health DRAXF 3.062 2.906 -5
Dura Pharm DURA 45.875 24.625 -46
Dusa Pharma DUSA 11.500 15.500 35
DynaGen (6) DYGND 1.400 0.562 -60
Ecogen EECN 1.937 2.687 39
Elan ELN 51.187 64.625 26
Embrex EMBX 5.312 5.750 8
Emisphere EMIS 18.625 17.875 -4
Endorex ENDR 5.500 6.187 12
EntreMed ENMD 11.312 12.812 13
Envirogen ENVG 1.500 1.250 -17
Enzo Biochem ENZ 14.625 15.750 8
Enzon ENZN 5.500 6.875 25
Epitope EPTO 5.000 6.875 38
Epix Medical EPIX 13.000 13.187 1
Ergo Science ERGO 15.250 15.062 -1
Ethical Hldgs ETHCY 3.125 3.000 -4
Flamel Tech FLMLY 1.812 5.125 183
GalaGen GGEN 1.875 1.625 -13
GelTex GELX 26.500 27.000 2
Gene Logic GLGC 8.000 7.625 -5
Genelabs GNLB 2.812 4.000 42
GeneMedicine GMED 5.062 2.875 -43
Genentech GNE 60.625 70.437 16
Genetronics GEB* 3.094 3.550 15
Genome Thera GENE 6.312 8.625 37
Genset GENXY 19.750 29.000 47
Gensia Sicor GNSA 5.812 5.000 -14
Genta GNTA 0.781 0.968 24
Genz Tiss Repair GENZL 6.875 8.625 25
Genzyme GENZ 27.750 32.000 15
Genzyme Trans GZTC 9.625 11.562 20
Geron GERN 8.250 12.375 50
Gilead Sciences GILD 38.250 36.000 -6
Gliatech GLIA 10.250 12.125 18
Guilford Pharm GLFD 20.125 22.000 9
Hemacare HEMA 0.468 0.687 47
Human Genome HGSI 39.750 39.812 0
Hycor Bio HYBD 1.562 1.750 12
Hyseq HYSQ 9.625 12.500 30
IBAH IBAH 3.750 5.343 42
Icos ICOS 18.312 15.250 -17
ID Biomed IDB* 3.400 5.150 51
IDEC Pharm IDPH 34.375 44.250 29
Idexx Labs IDXX 15.937 18.000 13
Igen IGEN 13.250 42.375 220
ILEX Oncology ILXO 7.375 10.125 37
ImClone Sys IMCL 8.125 8.312 2
Immucell ICCC 2.468 1.937 -22
Immucor BLUD 8.625 9.625 12
ImmuLogic IMUL 1.875 1.656 -12
Immune Resp IMNR 11.125 9.812 -12
Immunex IMNX 54.000 67.375 25
ImmunoGen IMGN 0.843 1.687 100
Immunomed IMMU 3.625 5.062 40
Incyte Pharm INCY 45.000 46.750 4
Inhale Ther Sys INHL 26.000 27.125 4
InKine Pharma INKP 1.375 1.343 -2
Innovir INVR 0.375 0.718 91
InSite Vision INSV 3.250 3.375 4
Integra LifeScien IART 4.437 4.437 0
Intercardia ITRC 17.875 20.375 14
Interferon Sci IFSC 8.687 7.125 -18
Interneuron IPIC 9.500 10.437 10
Intl Murex MURXF 10.062 12.625 25
Isis Pharm ISIP 12.312 15.250 24
La Jolla Pharm LJPC 4.437 3.875 -13
LeukoSite LKST 10.937 9.250 -15
Lidak Pharm LDAKA 2.375 1.781 -25
Life Tech LTEK 33.250 38.500 16
Lifecell LIFC 4.625 5.093 10
Lifecore Bio LCBM 21.875 23.375 7
Ligand LGND 12.875 15.937 24
Liposome Co LIPO 4.625 5.562 20
LJL Biosystems (7) LJLB 7.000 7.062 1
LXR Biotech LXR 2.375 3.812 61
Lynx Therapeutics LYNX 16.250 10.000 -38
MacroChem MCHM 9.125 11.187 23
Magainin MAGN 8.062 5.562 -31
Martek Bio MATK 8.250 15.187 84
Matritech NMPS 4.875 5.125 5
Matrix MATX 3.437 4.625 35
Maxim Pharma MMP 16.375 14.625 -11
Medarex MEDX 5.250 4.843 -8
Medical Science MSSI 5.625 4.000 -29
MedImmune MEDI 42.875 55.125 29
Megabios MBIO 14.250 9.250 -35
Meridian Diag KITS 10.125 12.750 26
Metra Biosys MTRA 3.625 2.250 -38
Microcide Pharma MCDE 8.875 8.625 -3
Micrologix Biotec MBI* 3.600 3.400 -6
Millennium MLNM 19.000 18.625 -2
Molec Dynam MDYN 16.250 14.437 -11
Molecular Bio MB 8.500 9.250 9
Molecular Devices MDCC 21.250 19.250 -9
Mycogen MYCO 18.750 18.187 -3
Myriad Genetics MYGN 24.250 22.375 -8
NABI NABI 3.406 3.062 -10
NaPro Biother NPRO 2.500 2.468 -1
NeoPharm NEO 5.250 3.812 -27
Neoprobe NEOP 6.000 4.562 -24
NeoRx Corp. NERX 5.625 5.343 -5
Neose Technol NTEC 15.250 13.625 -11
NeoTherapeutics NEOT 10.500 8.875 -15
Neurex NXCO 13.875 23.875 72
Neurocrine Biosci NBIX 7.875 8.125 3
Neurogen NRGN 13.500 15.375 14
NeXstar Pharm NXTR 11.375 11.500 1
North Am Vacc NVX 24.937 17.500 -30
Northfield Labs NFLD 9.125 10.000 10
Novavax NOX 5.000 4.062 -19
Noven NOVN 7.000 6.562 -6
NPS Pharm NPSP 7.750 7.375 -5
Oncor ONC 4.625 1.750 -62
OncorMed ONM 7.000 5.062 -28
Onyx Pharma ONXX 7.750 7.500 -3
OraVax ORVX 1.750 1.750 0
Organogenesis ORG 26.250 33.750 29
Ortec Int'l ORTC 13.062 19.750 51
OSI Pharma OSIP 6.750 6.125 -9
Osteotech OSTE 27.250 25.875 -5
Ostex Int'l OSTX 2.625 2.500 -5
OXiGENE OXGN 17.500 14.875 -15
Oxis Int'l OXIS 0.421 0.593 41
Pacific Pharma PHA 0.937 0.562 -40
Palatin Tech PLTN 5.875 6.125 4
Paracelsian PRLN 0.218 0.468 115
Parexel Intl PRXL 37.000 31.250 -16
PathoGenesis PGNS 37.125 33.500 -10
Penederm DERM 10.000 12.937 29
Pharma Prod Devlp PPDI 15.375 23.375 52
Pharmacopeia PCOP 16.000 18.750 17
Pharmacyclics PCYC 25.625 29.125 14
Pharmos PARS 2.000 2.875 44
Phoenix Intl PHX* 10.250 12.200 19
Procept (8) PRCTC 1.000 0.937 -6
ProCyte PRCY 0.937 1.500 60
Progenics Pharma PGNX 14.000 18.562 33
Progenitor PGEN 2.375 2.062 -13
Protein Design PDLI 40.000 39.250 -2
Protein Poly PPTI 1.625 1.281 -21
Qiagen QGENF 44.625 66.750 50
QLT PhotoTher QLTIF 11.125 17.375 56
Quidel QDEL 3.625 3.031 -16
Quintiles QTRN 38.250 48.187 26
Regeneron REGN 8.562 7.375 -14
Repligen RGEN 0.781 1.187 52
Ribi Immuno RIBI 3.687 5.750 56
Ribozyme Pharma RZYM 8.000 5.937 -26
SangStat Med SANG 40.500 31.875 -21
SciClone SCLN 3.437 3.968 15
Scios SCIO 10.000 12.187 22
Sepracor SEPR 40.062 42.625 6
Sequus Pharm SEQU 7.437 10.562 42
Shaman SHMN 4.937 5.031 2
Sheffield SHM 1.375 0.750 -45
SIBIA Neurosci SIBI 6.500 5.250 -19
Siga Pharma SGPH 4.625 4.250 -8
Somatogen SMTG 4.437 8.468 91
Sonus Pharma SNUS 33.125 24.500 -26
Sparta Pharm SPTA 0.375 0.343 -9
Stressgen Biotech SSB* 3.094 2.900 -6
Sugen SUGN 13.125 13.625 4
SunPharm SUNP 4.500 5.375 19
SuperGen SUPG 15.000 13.250 -12
Synaptic Pharma SNAP 10.875 12.750 17
Synbiotics SBIO 3.125 3.500 12
Synsorb Biotech SYB* 7.700 10.300 34
T Cell Sci TCEL 2.437 2.937 21
Targeted Genet TGEN 2.625 1.937 -26
Techniclone Int'l TCLN 2.187 0.781 -64
Teva Pharm TEVIY 47.312 42.750 -10
Texas Biotech TXB 6.187 7.187 16
Theratech THRT 8.000 9.875 23
Titan Pharma TTNPU 6.562 6.062 -8
Transcend Thera TSND 7.500 3.500 -53
Transgene (9) TRGNY 14.500 15.187 5
Transkaryotic TKTX 35.125 32.375 -8
Trega Biosciences TRGA 3.437 5.187 51
Triangle Pharma VIRS 14.625 15.750 8
Trimeris TRMS 13.000 7.500 -42
Trinity Bio TRIBY 1.968 2.187 11
Tripos TRPS 14.625 13.000 -11
Unigene UGNE 2.625 2.562 -2
UroCor UCOR 6.187 7.218 17
US Bioscience UBS 9.062 10.125 12
Vertex Pharm VRTX 33.000 31.937 -3
Vical VICL 12.000 15.750 31
VimRx VMRX 1.937 2.031 5
Vion Pharma VION 3.625 4.000 10
Viragen VRGN 1.093 2.406 120
ViroPharma VPHM 17.625 21.000 19
Virus Research VRII 4.500 4.125 -8
Visible Genetics VGINF 8.562 8.875 4
Vyrex VYRX 6.125 6.437 5
Vysis (10) VYSI 12.000 11.250 -6
Xenova Group XNVAY 2.250 3.125 39
XOMA XOMA 5.562 4.687 -16
Zonagen ZONA 18.187 22.000 21
NOTES:
1. As part of its acquisition of ImmunoTherapy Corp., AntiVirals Inc. (NASDAQ:AVII) has changed its name to AVI BioPharma. The trading symbol will stay the same.
2. Arris Pharmaceutical Corp. (NASDAQ:ARRS) completed its acquisition of Sequana Therapeutics Inc. (NASDAQ:SQNA) on 1/9/98. The new company is called Axys Pharmaceuticals Inc.; its stock started trading on NASDAQ under the symbol AXPH on 1/12/98.
3. Biocircuits Corp. (NASDAQ:BIOC) reverse-split its stock 1 for 2.5, effective 2/23/98. The historical prices have been adjusted accordingly.
4. Curagen Corp. (NASDAQ:CRGN) completed its IPO 3/18/98. The stock was priced at $11.50 per share.
5. Cypros Pharmaceutical Corp.'s stock, which had been trading on NASDAQ under the symbol CYPR, started trading instead on the American Stock Exchange under the symbol CYP, effective 1/15/98.
6. DynaGen Inc. (NASDAQ:DYGN) reverse-split its stock 1 for 10, effective 3/11/98. It is trading temporarily under the symbol DYGND. The historical prices have been adjusted accordingly.
7. LJL Biosystems Inc. (NASDAQ:LJLB) completed its IPO 3/13/98. The stock was priced at $7.00 per share.
8. Procept Inc. started trading on the NASDAQ SmallCap Market 3/27/98 under the symbol PRCTC.
9. Transgene SA (NASDAQ:TRGNY) completed its IPO 3/26/98. The stock was priced at $14.50 per American Depositary Share (ADS), with each ADS equaling 1/3 common share.
10. Vysis Inc. (NASDAQ:VYSI) completed its IPO 2/4/98. The stock was priced at $12.00 per share.
* The prices listed in the 12/31/97 column represent the 1997 closing prices or, for those stocks that started trading in 1998, the IPO prices. There are 308 stocks on this list; the average percent change year-to-date (YTD) is +9.31%.